Volume 10 Supplement 1

2nd Cross Company Respiratory Symposium

Meeting abstracts

Edited by Richard Knowles and Kathy H Abbott-Banner

The conference and publication of this supplement were supported by Pfizer. The organizing committee, which included a representative from Pfizer, was involved in selecting abstracts for oral and poster presentations at the meeting. RK is a scientific consultant on respiratory and inflammation models on drug discovery as well as CEO of an SME developing anti-inflammatory medicines. KAB has no competing interests.

2nd Cross Company Respiratory Symposium.

Horsham, UK6-7 September 2012

Concatenated PDF 10S1

Models of respiratory disease symposium

Authors: Kathy H Abbott-Banner, Anthony Holmes, Ian Adcock, Navin L Rao, Edward Barrett and Richard Knowles

Citation: Journal of Inflammation 2013 10(Suppl 1):I1

Content type: Meeting report Published on: 14 August 2013
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Assessment of the time course of chronic inflammation in the murine house dust mite model

Authors: Stephen M Jordan, Robert Carrington, David Lanham, James Cartwright, Rachel A Armstrong and Kenneth G Meecham

Citation: Journal of Inflammation 2013 10(Suppl 1):P1

Content type: Poster presentation Published on: 14 August 2013
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In-depth assessment of acute and chronic house dust mite-induced asthma mouse models

Authors: Rachel A Bunting, Josh Wertheimer, Zhao Zhou, Karyn Cochlin, Heather Deutsch, Holly Raymond, Ed Yurkow, Carol Anne Ogden and Ken Kilgore

Citation: Journal of Inflammation 2013 10(Suppl 1):P2

Content type: Poster presentation Published on: 14 August 2013
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Modulation of IL-17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease

Authors: C Hubeau, J Kubera, K Hammerman, J Wright J, M Denz, Y-T Juang and C Williams

Citation: Journal of Inflammation 2013 10(Suppl 1):P3

Content type: Poster presentation Published on: 14 August 2013
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Longitudinal characterisation of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods

Authors: Kumar Changani, Catherine Pereira, Simon Young, Robert Shaw, Simon P Campbell, Kashmira Pindoria, Steve Jordan, Katherine Wiley, Sarah Bolton, Tony Nials, Michael Haase, Mike Pedrick and Richard Knowles

Citation: Journal of Inflammation 2013 10(Suppl 1):P4

Content type: Poster presentation Published on: 14 August 2013
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Acidic mammalian chitinase is not a critical target for allergic airway disease in mice

Authors: LJ Fitz, C DeClercq, J Brooks, W Kuang, B Bates, D Demers, A Winkler, K Nocka, A Jiao, RM Greco, LE Mason, M Fleming, A Quazi, J Wright, S Goldman, C Hubeau…

Citation: Journal of Inflammation 2013 10(Suppl 1):P5

Content type: Poster presentation Published on: 14 August 2013
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Characterisation of the allergic phenotype resulting from a shortened HDM challenge protocol in mice

Authors: Sorif Uddin, Joanne Morley, Sara Hughes and Edith Hessel

Citation: Journal of Inflammation 2013 10(Suppl 1):P6

Content type: Poster presentation Published on: 14 August 2013
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Immunological characterisation of an acute murine model of lung inflammation and airway hyperreactivity

Authors: Kate L Dixon, Yee-Man Ching, Julie Coote and Neil Gozzard

Citation: Journal of Inflammation 2013 10(Suppl 1):P7

Content type: Poster presentation Published on: 14 August 2013
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Alterations in airway mechanics, inflammatory biomarkers and lung histopathology in a rat model of allergen-induced airway inflammation

Authors: Stephen M Jordan, Rachel A Armstrong, Jennifer Hincks, David Bell and Kenneth G Meecham

Citation: Journal of Inflammation 2013 10(Suppl 1):P8

Content type: Poster presentation Published on: 14 August 2013
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Brown Norway ovalbumin model: temporal profile of cytokines

Authors: Janice D Woodhouse, Alan Wilhelm, Michael Caniga, Malgorzata Gil, Jie Zhang-Hoover, Robbie McLeod, Lily Y Moy and Milenko Cicmil

Citation: Journal of Inflammation 2013 10(Suppl 1):P9

Content type: Poster presentation Published on: 14 August 2013
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Alternaria alternata induced inflammatory lung responses: a novel in vivo PK/PD model

Authors: Malgorzata Gil, Michael Caniga, Joseph Eckman, Robbie McLeod, Lily Moy, Alan Wilhelm, Janice Woodhouse, Jie Zhang-Hoover and Milenko Cicmil

Citation: Journal of Inflammation 2013 10(Suppl 1):P10

Content type: Poster presentation Published on: 14 August 2013
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Exploring the role of SYK in respiratory in vivo models

Authors: Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Yanlin Jia, Hongshi Yu, Stella Vincent, Richard Miller, Gissela Lieber, Xiomara Fernandez, Richard Chapman, Robbie McLeod, Lily Y Moy, Nancy Kelly, Emily Hickey, Michael A Crackower…

Citation: Journal of Inflammation 2013 10(Suppl 1):P11

Content type: Poster presentation Published on: 14 August 2013
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Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats

Authors: Sorif Uddin, Sara Hughes and Edith Hessel

Citation: Journal of Inflammation 2013 10(Suppl 1):P12

Content type: Poster presentation Published on: 14 August 2013
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Effect of the circadian cycle in Late Asthmatic Response (LAR). Comparison between two allergic asthma models in rats and mice

Authors: Raquel Otal, Sandra Muñoz, Elena Calama, Isabel Pagán, Félix Gil, Núria Torán, Montserrat Miralpeix and Jorge De Alba

Citation: Journal of Inflammation 2013 10(Suppl 1):P13

Content type: Poster presentation Published on: 14 August 2013
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A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies

Authors: Edward G Barrett, Karin Rudolph, Maura Matthews, Greg Dietsch and Robert Hershberg

Citation: Journal of Inflammation 2013 10(Suppl 1):P14

Content type: Poster presentation Published on: 14 August 2013
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Assessment of multiple pharmacological mechanisms in the ascaris sensitive sheep model of allergic asthma

Authors: Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Robbie McLeod, Lily Y Moy, Michael A Crackower, Thomas Miller, William M Abraham and Milenko Cicmil

Citation: Journal of Inflammation 2013 10(Suppl 1):P15

Content type: Poster presentation Published on: 14 August 2013
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Development of a model of Ascaris Suum antigen-induced pulmonary inflammation in nonhuman primates

Authors: Andrea G Bree, Franklin J Schlerman, Michael D Wadanoli, I-Ming Wang, Samuel J Goldman and Joseph P Sypek

Citation: Journal of Inflammation 2013 10(Suppl 1):P16

Content type: Poster presentation Published on: 14 August 2013
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Plasmacytoid dendritic cells downregulate the allergen induced T cell proliferation in a human in vitro allergy model

Authors: Frank Schaumann, Armin Braun and Meike Müller

Citation: Journal of Inflammation 2013 10(Suppl 1):P17

Content type: Poster presentation Published on: 14 August 2013
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Mast cell mediators cause the early allergic bronchoconstriction in guinea pigs in vivo: a model of relevance to asthma

Authors: Jason P Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L Rao and Mikael Adner

Citation: Journal of Inflammation 2013 10(Suppl 1):P18

Content type: Poster presentation Published on: 14 August 2013
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Strategies to mimic virally induced asthmatic exacerbations: the use of rhinovirus and influenza in acute and chronic mouse models

Authors: RJ Shaw, M Sowa, MS Pedrick, M Fife, AT Nials, RG Knowles and E Hessel

Citation: Journal of Inflammation 2013 10(Suppl 1):P19

Content type: Poster presentation Published on: 14 August 2013
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Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation

Authors: Sabine Rochlitzer, Heinz-Gerd Hoymann, Armin Braun and Meike Müller

Citation: Journal of Inflammation 2013 10(Suppl 1):P20

Content type: Poster presentation Published on: 14 August 2013
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Poly I:C causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund's complete adjuvant

Authors: Jorge De Alba, Raquel Otal, Elena Calama, Félix Gil, Neil Gozzard and Montserrat Miralpeix

Citation: Journal of Inflammation 2013 10(Suppl 1):P21

Content type: Poster presentation Published on: 14 August 2013
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Mouse model of HDM induced airway inflammation + influenza or RSV. Effects of steroid

Authors: Dave Lamb, Christina Muir, Debbie Chappell, Hiroki Mori, Nicole Parker, Katy Hulland, Dominique Westbrook, Umar Burki, Jenny Hincks, Tony White, Vittorio Spampinato, Helen Bright and Steve Evans

Citation: Journal of Inflammation 2013 10(Suppl 1):P22

Content type: Poster presentation Published on: 14 August 2013
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Influenza exacerbations in an acute and chronic house dust mite ‘asthma’ model

Authors: Suzanne M Bal, Lara Ravanetti, Annemiek Dijkhuis and Rene Lutter

Citation: Journal of Inflammation 2013 10(Suppl 1):P23

Content type: Poster presentation Published on: 14 August 2013
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Antiviral effect of eosinophils in respiratory tract infection with influenza virus in mice

Authors: Suzanne M Bal, Annemiek Dijkhuis, Koen van der Sluijs and Rene Lutter

Citation: Journal of Inflammation 2013 10(Suppl 1):P24

Content type: Poster presentation Published on: 14 August 2013
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Preclinical animal models of COPD

Authors: Ross Vlahos

Citation: Journal of Inflammation 2013 10(Suppl 1):P25

Content type: Poster presentation Published on: 14 August 2013
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Characterization of MMP-9 and -12 KO mice in a model of acute smoke exposure

Authors: Franklin J Schlerman, John E Kubera, Stephen P Pazdziorko, Michael R Bowman, Bruce A Jacobson, Margaret Fleming, Cara MM Williams and Joseph P Sypek

Citation: Journal of Inflammation 2013 10(Suppl 1):P26

Content type: Poster presentation Published on: 14 August 2013
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Relative sensitivity of mice to inhaled ozone and cigarette smoke exposure

Authors: Rachel A Armstrong, Stephen M Jordan, Emma McConnell, Robert Carrington, Debbie Rodgers and Kenneth G Meecham

Citation: Journal of Inflammation 2013 10(Suppl 1):P27

Content type: Poster presentation Published on: 14 August 2013
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A translational approach to test anti-inflammatory drugs in a LPS induced acute lung inflammation model in the common marmoset (Callithrix jacchus)

Authors: S Seehase, S Switalla, V Neuhaus, M Zöller, FJ Kaup, C Schlumbohm, E Fuchs, HD Lauenstein, K Sewald, JM Hohlfeld, A Braun and S Knauf

Citation: Journal of Inflammation 2013 10(Suppl 1):P28

Content type: Poster presentation Published on: 14 August 2013
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Lipopolysaccharide (LPS) segmental lung challenge in nonhuman primates – a model of airway inflammation

Authors: Franklin J Schlerman, Andrea G Bree, Michael D Wadanoli, Samuel J Goldman, Cara MM Williams and Joseph P Sypek

Citation: Journal of Inflammation 2013 10(Suppl 1):P29

Content type: Poster presentation Published on: 14 August 2013
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Steroid insensitive respiratory inflammation - an acute tobacco smoke model

Authors: Hemanth Ramaprakash, Jason Riley and Navin L Rao

Citation: Journal of Inflammation 2013 10(Suppl 1):P30

Content type: Poster presentation Published on: 14 August 2013
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Steroid-insensitive tobacco smoke-induced lung inflammation models in the mouse

Authors: V Russell, D Spicer, P Woodman, A Connolly and A Young

Citation: Journal of Inflammation 2013 10(Suppl 1):P31

Content type: Poster presentation Published on: 14 August 2013
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A mouse model of acute exacerbations of lung inflammation in COPD with both steroid-sensitive and steroid-insensitive features

Authors: V Russell, A Connolly, C Jagger, D Spicer, P Woodman, J Dlugozima and A Young

Citation: Journal of Inflammation 2013 10(Suppl 1):P32

Content type: Poster presentation Published on: 14 August 2013
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Interleukin-6 neutralization alleviates acute exacerbation-like disease in a model of cigarette smoke-induced pulmonary inflammation

Authors: John Kubera, Katherine Hammerman, Cara MM Williams and Cedric Hubeau

Citation: Journal of Inflammation 2013 10(Suppl 1):P33

Content type: Poster presentation Published on: 14 August 2013
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A COPD-like model of viral exacerbation: synergistic effects with smoke and poly I:C

Authors: F Schlerman, J Kubera, M Fleming, K Nocka and C Williams

Citation: Journal of Inflammation 2013 10(Suppl 1):P34

Content type: Poster presentation Published on: 14 August 2013
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Strategies to improve lung absorption of intratracheally administered compounds in Drug Discovery

Authors: Elena Calama, Montserrat Vives, Isabel Ramis, Sonia Espinosa, Juan Pérez, Josep Maria Huerta, Jorge De Alba and Peter Eichhorn

Citation: Journal of Inflammation 2013 10(Suppl 1):P35

Content type: Poster presentation Published on: 14 August 2013
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Dry powder inhaled compound delivery for early pre-clinical in vivo efficacy studies

Authors: Robert Ives, Lindsay Butterfield, John Farr, Shaun Bater, Tony Nials, Lewis Entwistle, Doug Ball and Edith Hessel

Citation: Journal of Inflammation 2013 10(Suppl 1):P36

Content type: Poster presentation Published on: 14 August 2013
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Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling

Authors: Baktybek Kojonazarov, Akylbek Sydykov, Soni Savai Pullamsetti, Himal Luitel, Bhola K Dahal, Djuro Kosanovic, Xia Tian, Matthaeus Majewski, Christin Baumann, Steve Evans, Peter Phillips, David Fairman, Neil Davie, Chris Wayman, Iain Kilty, Norbert Weissmann…

Citation: Journal of Inflammation 2013 10(Suppl 1):P37

Content type: Poster presentation Published on: 14 August 2013
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Therapeutic efficacy of Sunitinib and other broad spectrum receptor tyrosine kinase inhibitors (RTKI) in bleomycin-induced pulmonary fibrosis

Authors: D Knoerzer, T Baginski, K Wade, C Fan, S Rapp, K Regina, F Shih, M Burney, S Rouw and D Welsch

Citation: Journal of Inflammation 2013 10(Suppl 1):P38

Content type: Poster presentation Published on: 14 August 2013
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Considerations for therapeutic intervention models of pulmonary fibrosis

Authors: JA Wilder, M Doyle-Eisele, KM Gott, Y Shi, R Guilmette, A Gigliotti, J McDonald and IO Rosas

Citation: Journal of Inflammation 2013 10(Suppl 1):P39

Content type: Poster presentation Published on: 14 August 2013
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Do allergic dogs exhibit features of a severe steroid-resistant allergic airway phenotype?

Authors: Edward G Barrett, Christopher M Royer, Karin Rudolph and Phillip J Kuehl

Citation: Journal of Inflammation 2013 10(Suppl 1):P40

Content type: Poster presentation Published on: 14 August 2013
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Viral exacerbation of chronic airway inflammation in BALB/c mice sensitized with house dust mite (HDM): a role for corticosteroids?

Authors: Edward G Barrett, Al P Senft, Jennifer Nicodem, Dylan Armes, Aaron Gaskins and Ginevra Giannini

Citation: Journal of Inflammation 2013 10(Suppl 1):P41

Content type: Poster presentation Published on: 14 August 2013
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