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Journal of Inflammation


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  1. Content type: Research

    Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im...

    Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock

    Citation: Journal of Inflammation 2018 15:5

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  2. Content type: Research

    Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ...

    Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang

    Citation: Journal of Inflammation 2018 15:4

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  3. Content type: Research

    Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve...

    Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin

    Citation: Journal of Inflammation 2018 15:3

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  4. Content type: Research

    In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel...

    Authors: T. Smith, L. Engelbrecht and C. Smith

    Citation: Journal of Inflammation 2018 15:2

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  5. Content type: Research

    Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis...

    Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye

    Citation: Journal of Inflammation 2018 15:1

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  6. Content type: Research

    An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust eff...

    Authors: David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek and Sharath Hegde

    Citation: Journal of Inflammation 2017 14:28

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  7. Content type: Research

    Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 tr...

    Authors: Nina Falcon Bærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen and Ole Hyldegaard

    Citation: Journal of Inflammation 2017 14:27

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  8. Content type: Review

    Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included...

    Authors: Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong and Louis Tong

    Citation: Journal of Inflammation 2017 14:26

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  9. Content type: Research

    Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) h...

    Authors: Lei Yang, Lei Shen, Yue Li, Yanxia Li, Shijie Yu and Shanshan Wang

    Citation: Journal of Inflammation 2017 14:25

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  10. Content type: Research

    Inflammatory cytokines have been demonstrated to be involved in developing insulin resistance and type-2 diabetes (T2D). Natural antibodies in the circulation have protective effects on common diseases in huma...

    Authors: Weiyi Cai, Cailing Qiu, Hongyu Zhang, Xiangyun Chen, Xuan Zhang, Qingyong Meng and Jun Wei

    Citation: Journal of Inflammation 2017 14:24

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  11. Content type: Research

    Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a ...

    Authors: Matthew J. Bradley, Diego A. Vicente, Benjamin A. Bograd, Erin M. Sanders, Crystal L. Leonhardt, Eric A. Elster and Thomas A. Davis

    Citation: Journal of Inflammation 2017 14:23

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  12. Content type: Research

    This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vi...

    Authors: Maria Luisa Molina, Julia Guerrero, John A. Cidlowski, Héctor Gatica and Annelise Goecke

    Citation: Journal of Inflammation 2017 14:22

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  13. Content type: Research

    The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced p...

    Authors: Tetsuya Yokoyama, Toyoshi Yanagihara, Kunihiro Suzuki, Naoki Hamada, Kazuya Tsubouchi, Saiko Ogata-Suetsugu, Hironori Mikumo, Chika Ikeda-Harada, Takashige Maeyama, Kazuyoshi Kuwano and Yoichi Nakanishi

    Citation: Journal of Inflammation 2017 14:20

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  14. Content type: Short Report

    In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, us...

    Authors: Torbjörn Karlsson

    Citation: Journal of Inflammation 2017 14:21

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  15. Content type: Research

    Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be invol...

    Authors: Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö and Stefan Söderberg

    Citation: Journal of Inflammation 2017 14:19

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  16. Content type: Research

    Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators ...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan

    Citation: Journal of Inflammation 2017 14:17

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  17. Content type: Review

    Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transd...

    Authors: Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang and Ke Jiang

    Citation: Journal of Inflammation 2017 14:16

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  18. Content type: Research

    Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary c...

    Authors: Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra and Anurag Kuhad

    Citation: Journal of Inflammation 2017 14:14

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  19. Content type: Research

    Traumatic brain injury (TBI) is a public health issue. As the major complaint in 51% of TBI patients, chronic pain is an important aspect in TBI treatment. Tetramethylpyrazine (TMP) is an important compound in Li...

    Authors: Zhijing Wang, Qi Wang, Cuijie Wang, Xiuzhen Xu and Hongmei Yu

    Citation: Journal of Inflammation 2017 14:13

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  20. Content type: Review

    The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INte...

    Authors: Yang Li, Heather L. Wilson and Endre Kiss-Toth

    Citation: Journal of Inflammation 2017 14:11

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  21. Content type: Research

    The red cell distribution width (RDW) is a widely available, inexpensive, and highly reproducible test that reflects the range of the red cell sizes. Any process that releases reticulocytes in the circulation ...

    Authors: Tom Schepens, Jozef J. De Dooy, Walter Verbrugghe and Philippe G. Jorens

    Citation: Journal of Inflammation 2017 14:12

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  22. Content type: Short report

    Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular e...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Journal of Inflammation 2017 14:10

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Affiliated with the British Inflammation Research Association (BIRAs).

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