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  1. Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induced acute liver injury (APAP-ALI) and there are limited treatments for this condition. AT...

    Authors: Jennifer A. Cartwright, Joanna P. Simpson, Natalie Z. M. Homer and Adriano G. Rossi
    Citation: Journal of Inflammation 2023 20:20
    Content type: Research Published on:

  2. Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely affecting patients’ physical and mental health. Accumulating evidence indicated that the immu...

    Authors: Xiangsheng Zhang, Jiurong Cheng, Yingdong Deng, Caiyun Guo, Yu Cao, Suo Wang, Chenxi Zhou, Ziqiang Lin, Simin Tang and Jun Zhou
    Citation: Journal of Inflammation 2023 20:19
    Content type: Research Published on:

  3. To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysr...

    Authors: S. C. Bergkamp, M. J. Wahadat, A. Salah, T. W. Kuijpers, V. Smith, S. W. Tas, J. M. van den Berg, S. Kamphuis and D. Schonenberg-Meinema
    Citation: Journal of Inflammation 2023 20:18
    Content type: Review Published on:

  4. Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and deat...

    Authors: Yawen Wu, Shilin Wei, Xiangyang Wu, Yongnan Li and Xue Han
    Citation: Journal of Inflammation 2023 20:17
    Content type: Review Published on:

  5. Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therape...

    Authors: Yinjiaozhi Li, Ruoming Tan, Ranran Li, Rui Tian, Zhaojun Liu, Xiaoli Wang, Erzhen Chen, Tingting Pan and Hongping Qu
    Citation: Journal of Inflammation 2023 20:16
    Content type: Research Published on:

  6. The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC),...

    Authors: Fyyaz Siddiqui, Denis Gallagher, Hannah Shuster-Hyman, Lianet Lopez, Andrée Gauthier-Fisher and Clifford L Librach
    Citation: Journal of Inflammation 2023 20:15
    Content type: Research Published on:

  7. Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, there is no adequate therapeutic strategy to reverse the progression of OA. Many natural pl...

    Authors: Qing Ding, Ruizhuo Zhang, Gaohong Sheng, Tianqi Wang, Shaoze Jing, Tian Ma, Shanxi Wang, Hongqi Zhao, Hua Wu and Wenkai Li
    Citation: Journal of Inflammation 2023 20:14
    Content type: Research Published on:

  8. Acute lung injury (ALI) is a life-threatening condition that fundamentally results from inflammation and edema in the lung. There are no effective treatments available for clinical use. Previously, we found th...

    Authors: Yeomyeong Kim, Cho-Rong Bae, Dongyeop Kim, Hyejeong Kim, Sunghye Lee, Haiying Zhang, Minyoung Noh, Young-Myeong Kim, Naoki Mochizuki and Young-Guen Kwon
    Citation: Journal of Inflammation 2023 20:13
    Content type: Research Published on:

  9. Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation invo...

    Authors: Matti Hoch, Suchi Smita, Konstantin Cesnulevicius, Myron Schultz, David Lescheid, Olaf Wolkenhauer and Shailendra Gupta
    Citation: Journal of Inflammation 2023 20:12
    Content type: Research Published on:

  10. The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and...

    Authors: Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham…
    Citation: Journal of Inflammation 2023 20:11
    Content type: Review Published on:

  11. Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening res...

    Authors: Petra Kosutova, Pavol Mikolka, Daniela Mokra and Andrea Calkovska
    Citation: Journal of Inflammation 2023 20:10
    Content type: Research Published on:

  12. Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) ...

    Authors: Xinkun Cheng, Torsten Lowin, Nadine Honke and Georg Pongratz
    Citation: Journal of Inflammation 2023 20:9
    Content type: Research Published on:

  13. Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear Factor-κappa B (NF-κB) is a critical transcription factors family of the inflammatory pa...

    Authors: Jiali Gan, Lin Guo, Xiaolu Zhang, Qun Yu, Qiuyue Yang, Yilin Zhang, Wenyun Zeng, Xijuan Jiang and Maojuan Guo
    Citation: Journal of Inflammation 2023 20:8
    Content type: Review Published on:

  14. The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related a...

    Authors: Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen, Yi Liu, Yi Zhao and Martin Herrmann
    Citation: Journal of Inflammation 2023 20:7
    Content type: Research Published on:

  15. Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections....

    Authors: Sofia Malm Tillgren, Juan José Nieto-Fontarigo, Samuel Cerps, Sangeetha Ramu, Mandy Menzel, Irma Mahmutovic Persson, Anja Meissner, Hamid Akbarshahi and Lena Uller
    Citation: Journal of Inflammation 2023 20:6
    Content type: Research Published on:

  16. Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. T...

    Authors: Xinxin Zhang, Xingsheng Wang, Li Sun, Guangsheng Gao and Yun Li
    Citation: Journal of Inflammation 2023 20:5
    Content type: Research Published on:

  17. Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable option for treating these disorders. Previous work indicated pretreatment with beta-funalt...

    Authors: Stephanie Myers, Kelly McCracken, Daniel J. Buck, J. Thomas Curtis and Randall L. Davis
    Citation: Journal of Inflammation 2023 20:4
    Content type: Research Published on:

  19. Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellula...

    Authors: Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma and Qingrui Yang
    Citation: Journal of Inflammation 2023 20:2
    Content type: Review Published on:

  20. Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under physiological conditions are typ...

    Authors: Ali Saeedi-Boroujeni, Daryush Purrahman, Ali Shojaeian, Łukasz A. Poniatowski, Fatemeh Rafiee and Mohammad-Reza Mahmoudian-Sani
    Citation: Journal of Inflammation 2023 20:1
    Content type: Review Published on:

  21. Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein exp...

    Authors: Tapas Patra and Ranjit Ray
    Citation: Journal of Inflammation 2022 19:28
    Content type: Research Published on:

  22. Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternat...

    Authors: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo and Benedetta Cinque
    Citation: Journal of Inflammation 2022 19:27
    Content type: Research Published on:

  23. The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Although IL-17A/F...

    Authors: Anthony Altieri, Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Breann Recksiedler, Victor Spicer, Pieter S Hiemstra, Andrew J Halayko and Neeloffer Mookherjee
    Citation: Journal of Inflammation 2022 19:26
    Content type: Research Published on:

  24. Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed asthma– chronic obstructive pulmonary disease overlap (ACO). ACO is heterogeneous cond...

    Authors: Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An and Jung Hur
    Citation: Journal of Inflammation 2022 19:25
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Inflammation 2023 20:3

  25. Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is...

    Authors: Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li and Beixian Zhou
    Citation: Journal of Inflammation 2022 19:24
    Content type: Research Published on:

  26. The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflammation and liver failure in sepsis. Neutrophils have the highest CXCR2 expression in mi...

    Authors: Na Liu, Michael Bauer and Adrian T. Press
    Citation: Journal of Inflammation 2022 19:23
    Content type: Review Published on:

  27. The behavior of neutrophils is very important for the resolution of inflammation and tissue repair. People have used advanced imaging techniques to observe the phenomenon of neutrophils leaving the injured or ...

    Authors: Qichao Xu, Wenqi Zhao, Mingyang Yan and Hongxia Mei
    Citation: Journal of Inflammation 2022 19:22
    Content type: Review Published on:

  28. Obesity and insulin resistance (IR), the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation. Bariatric surgery leads to a considerable reduction in the a...

    Authors: Sara Coletta, Elisabetta Trevellin, Marisa Benagiano, Jacopo Romagnoli, Chiara Della Bella, Mario Milco D’Elios, Roberto Vettor and Marina de Bernard
    Citation: Journal of Inflammation 2022 19:21
    Content type: Brief Report Published on:

  29. Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflamm...

    Authors: Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E. Van Eyk and Justyna Fert-Bober
    Citation: Journal of Inflammation 2022 19:20
    Content type: Research Published on:

  30. Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, bioavail...

    Authors: Sara Socorro Faria, Anuruddika Jayawanthi Fernando, Vladmir Cláudio Cordeiro de Lima, Adriano Giorgio Rossi, Juliana Maria Andrade de Carvalho and Kelly Grace Magalhães
    Citation: Journal of Inflammation 2022 19:19
    Content type: Review Published on:

  31. Chronic obstructive pulmonary disease (COPD) is a major health issue resulting in significant mortality worldwide. Due to the high heterogeneity and unclear pathogenesis, the management and therapy of COPD are...

    Authors: Xuanqi Liu, Zheng Li, Yang Zheng, Wenhao Wang, Peiqing He, Kangwei Guan, Tao Wu, Xiaojun Wang and Xuelin Zhang
    Citation: Journal of Inflammation 2022 19:18
    Content type: Research Published on:

  32. Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatm...

    Authors: Jiping Zhao, Hong Wang, Jintao zhang, Fuwei Ou, Junfei Wang, Tian Liu and Jinxiang Wu
    Citation: Journal of Inflammation 2022 19:17
    Content type: Research Published on:

  33. Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protecti...

    Authors: Hongling Yin, Yajing Feng, Yi Duan, Shaolin Ma, Zhongliang Guo and Youzhen Wei
    Citation: Journal of Inflammation 2022 19:16
    Content type: Research Published on:

  35. With the incidence of hypertension increasing worldwide, more and more the mechanisms of hypertension from the perspective of immunity have found. Intestinal microbiota as well as its metabolites relationship ...

    Authors: Ze-Jun Yang, Tian-Tian Wang, Bo-Ya Wang, Han Gao, Cheng-Wei He, Hong-Wei Shang, Xin Lu, Ying Wang and Jing-Dong Xu
    Citation: Journal of Inflammation 2022 19:14
    Content type: Review Published on:

  36. Angiotensin-converting enzyme 2 (ACE2) has been reported to be the main receptor for SARS-CoV-2 infection of host cells. Understanding the changes in bronchoalveolar epithelial cells after SARS-CoV-2 infection...

    Authors: Zhiqin Deng, Qin Li, Yongshen Li, Zhenhan Deng, Xiaoqiang Chen, Zhe Zhao, Guganghui Wang, Daping Wang, Jianquan Liu and Wencui Li
    Citation: Journal of Inflammation 2022 19:13
    Content type: Research Published on:

  37. Macrophages play a central role in inflammation by phagocytosing invading pathogens, apoptotic cells and debris, as well as mediating repair of tissues damaged by trauma. In order to do this, these dynamic cel...

    Authors: Nicole Brace, Ian L. Megson, Adriano G. Rossi, Mary K. Doherty and Phillip D. Whitfield
    Citation: Journal of Inflammation 2022 19:12
    Content type: Research Published on:

  38. Serous ovarian carcinoma is the most common type of ovarian carcinoma. Tumor-associated macrophages (TAMs) promote ovarian cancer progression. Most macrophages are generated by monocyte differentiation. Lysoph...

    Authors: Ying Feng, Meizhu Xiao, Guangming Cao, Hao Liu, Yanfang Li, Shuzhen Wang, Stan Zijtveld, Bert Delvoux, Sofia Xanthoulea, Andrea Romano, Chongdong Liu and Zhenyu Zhang
    Citation: Journal of Inflammation 2022 19:11
    Content type: Research Published on:

  40. Severe sepsis and its subsequent complications cause high morbidity and mortality rates worldwide. The lung is one of the most vulnerable organs sensitive to the sepsis-associated inflammatory storm and usuall...

    Authors: Shuai Mao, Jian Lv, Meng Chen, Ningning Guo, Yu Fang, Jingjing Tong, Xianghu He, Gang Wu and Zhihua Wang
    Citation: Journal of Inflammation 2022 19:9
    Content type: Research Published on:

  41. Influenza A virus (IAV) triggers acute exacerbation of chronic obstructive pulmonary disease (AECOPD), but the molecular mechanisms remain unclear. In this study, we investigated the role of IAV induced NLRP3 ...

    Authors: Shuang Ji, Meng-Yuan Dai, Yun Huang, Xiang-Chun Ren, Meng-Long Jiang, Jin-Ping Qiao, Wen-Ying Zhang, Yuan-Hong Xu, Ji-Long Shen, Ren-Quan Zhang and Guang-He Fei
    Citation: Journal of Inflammation 2022 19:8
    Content type: Research Published on:

  42. Long-term inhalation of cigarette smoke is considered to be one of the main causes of bronchial epithelioid cell damage, but its underlying mechanism has to be further clarified.

    Authors: Wei Zhang, Yibin Zhang and Qi Zhu
    Citation: Journal of Inflammation 2022 19:7
    Content type: Research Published on:

  44. Behçet’s disease (BD) is a multisystem autoinflammatory disease characterised by mucosal ulceration, ocular, neural, joint and skin inflammation. The cause of BD is not known but there is a strong genetic asso...

    Authors: Mariam Murad, Liying Low, Matthew Davidson, Philip I. Murray, Saaeha Rauz and Graham R. Wallace
    Citation: Journal of Inflammation 2022 19:5
    Content type: Research Published on:

  45. It has been reported that hsa_circRNA_100833 (identified as circFADS2) and miR-133a play opposite roles in LPS-induced cell apoptosis, which contributes to the development of sepsis. This study was carried out...

    Authors: Fang Niu, Xiaofeng Liang, Jindi Ni, Zhuye Xia, Lijing Jiang, Hong Wang, Hongjie Liu, Guofeng Shen and Xiang Li
    Citation: Journal of Inflammation 2022 19:4
    Content type: Research Published on:

  46. A hydro ethanol extract of the stem bark of Holarrhena floribunda (HFE) has been shown to be effective in the management of acute inflammation. This study was to evaluate usefulness of the extract for the managem...

    Authors: Stephen Antwi, Daniel Oduro-Mensah, Jerry Asiedu-Larbi, Ebenezer Oduro-Mensah, Olga Quasie, Clara Lewis, David Darko-Obiri, Augustine Ocloo and Laud Kenneth Okine
    Citation: Journal of Inflammation 2022 19:3
    Content type: Research Published on:

  47. Acute kidney injury (AKI) is a syndrome characterized by rapid loss of excretory function of kidney. Both exercise and some diets have been shown to increase silent information regulator (SIRT1) expression lea...

    Authors: Nazanin Sabet, Zahra Soltani, Mohammad Khaksari and Alireza Raji-Amirhasani
    Citation: Journal of Inflammation 2022 19:2
    Content type: Research Published on:

  48. TRIP6 is a zyxin family member that serves as an adaptor protein to regulate diverse biological processes. In prior reports, TRIP6 was shown to play a role in regulating inflammation. However, its in vivo role...

    Authors: Yun Yang, Xiu-Ming Li, Jing-Ru Wang, Yan Li, Wen-Long Ye, Yi Wang, Yu-Xuan Liu, Zhi-Yong Deng, Wen-Juan Gan and Hua Wu
    Citation: Journal of Inflammation 2022 19:1
    Content type: Short Report Published on:

  49. Studies have shown that ginsenoside R3 (Rg3) plays a protective role in sepsis-induced organ injuries and mitochondrial dysfunction. Long noncoding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) is regarded as...

    Authors: Pan Wu, Xiao Yu, Yue Peng, Qian-Lu Wang, Long-Tian Deng and Wei Xing
    Citation: Journal of Inflammation 2021 18:31
    Content type: Research Published on:

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