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  1. Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resu...

    Authors: Huakang Zhou, Dilaware Khan, Sajid Muhammad Hussain, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius and Sajjad Muhammad
    Citation: Journal of Inflammation 2023 20:41
    Content type: Research Published on:

  2. The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process in the propagation of viral infection. The main consequence of COVID-19 is the inductio...

    Authors: Bianca Vezzani, Mariasole Perrone, Marianna Carinci, Laura Palumbo, Alberto Tombolato, Denis Tombolato, Claudio Daminato, Valentina Gentili, Roberta Rizzo, Gianluca Campo, Luca Morandi, Alberto Papi, Savino Spadaro, Paolo Casolari, Marco Contoli, Paolo Pinton…
    Citation: Journal of Inflammation 2023 20:40
    Content type: Research Published on:

  3. Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects, but underlying mechanisms remain to be fully uncovered. Based on recent exploratory ev...

    Authors: Mizanur Rahman, Shanzina Iasmin Sompa, Micol Introna, Swapna Upadhyay, Koustav Ganguly and Lena Palmberg
    Citation: Journal of Inflammation 2023 20:39
    Content type: Research Published on:

  4. Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how H...

    Authors: Kristian Barry, Christopher Harpur, Maggie Lam, Michelle D. Tate and Ashley Mansell
    Citation: Journal of Inflammation 2023 20:38
    Content type: Research Published on:

  5. Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effect and underlying mechanism of butyrate on myasthenia gravis (MG) remain unclear. The c...

    Authors: Jing Sun, Juanjuan Chen, Qinfang Xie, Mengjiao Sun, Wenjing Zhang, Hongxia Wang, Ning Liu, Qi Wang and Manxia Wang
    Citation: Journal of Inflammation 2023 20:37
    Content type: Research Published on:

  6. Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD). Considering the excessive end...

    Authors: Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang and Ganggang Yu
    Citation: Journal of Inflammation 2023 20:36
    Content type: Research Published on:

  7. Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was down...

    Authors: Mengqi Guo, Zongyi Xia, Yefeng Hong, Hongwei Ji, Fuhai Li, Wenheng Liu, Shaohua Li, Hui Xin, Kai Tan and Zhexun Lian
    Citation: Journal of Inflammation 2023 20:35
    Content type: Research Published on:

  8. Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonary diseases, and we are now lack of effective therapeutic methods. Inflammatory response...

    Authors: Chunguang Yan, Jing Chen, Huifang Tang, Chunmin Deng, Qi Zhang and Ximo Wang
    Citation: Journal of Inflammation 2023 20:34
    Content type: Research Published on:

  9. When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type and the anti-inflammatory M2-type, both of which perform almost enti...

    Authors: Tingting Xia, Shengping Fu, Ruilin Yang, Kang Yang, Wei Lei, Ying Yang, Qian Zhang, Yujie Zhao, Jiang Yu, Limei Yu and Tao Zhang
    Citation: Journal of Inflammation 2023 20:33
    Content type: Review Published on:

  10. Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long latency period presents opportunities for early detection, lifestyle modification and inter...

    Authors: Erik Fung, Eunice Y. S. Chan, Kwan Hung Ng, Ka Man Yu, Huijun Li and Yulan Wang
    Citation: Journal of Inflammation 2023 20:32
    Content type: Review Published on:

  11. An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various sepsis-related immune cell defects. Alternative splicing (AS), as a sepsis-related immu...

    Authors: Dilixiati Tuerdimaimaiti, Buzukela Abuduaini, Shaotao Kang, Jinliang Jiao, Mengchen Li, Wolazihan Madeniyati, Baihetinisha Tuerdi, Gulisitan Aili, Reyila Tuerhong and Ajiguli Kulaxi
    Citation: Journal of Inflammation 2023 20:31
    Content type: Brief Report Published on:

  12. To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhibition, have been used to reduce pain and as an alternative treatment for uncomplicated ...

    Authors: Soumitra Mohanty, Ciska Lindelauf, John Kerr White, Andrea Scheffschick, Ewa Ehrenborg, Isak Demirel, Hanna Brauner and Annelie Brauner
    Citation: Journal of Inflammation 2023 20:30
    Content type: Research Published on:

  13. The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to ...

    Authors: Yinzhou Zhang, Junying Wei, Xinyuan Wu, Mengting Jiang, Wuhua Ma and Yuhui Li
    Citation: Journal of Inflammation 2023 20:29
    Content type: Research Published on:

  14. Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic obstructive pulmonary disease (COPD). Sodium pyruvate (NaPyr) is a natural antioxidant...

    Authors: Ziwen Zhao, Zhao Xu, Jingwen Chang, Liwei He, Zijin Zhang, Xiaoyu Song, Xianbang Hou, Fangtian Fan and Zhijun Jiang
    Citation: Journal of Inflammation 2023 20:28
    Content type: Research Published on:

  16. According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite a growing public awareness of the harmful effects of air pollution on human health, th...

    Authors: Adrianna Gałuszka-Bulaga, Karolina Tkacz, Kazimierz Węglarczyk, Maciej Siedlar and Jarek Baran
    Citation: Journal of Inflammation 2023 20:26
    Content type: Research Published on:

  17. Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable biomarkers accurate to gestational weeks for infectious PTB prediction clinically. Infect...

    Authors: Jiayi Li, Jianrong Ge, Na Ran, Changwu Zheng, Yumeng Fang, Danna Fang, Qian Yang and Yeling Ma
    Citation: Journal of Inflammation 2023 20:25
    Content type: Review Published on:

  18. Acute liver failure (ALF) is one of the most common life-threatening diseases in adults without previous liver disease. Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that is widely d...

    Authors: Danmei Zhang, Chunxia Shi, Qingqi Zhang, Yukun Wang, Jin Guo and Zuojiong Gong
    Citation: Journal of Inflammation 2023 20:24
    Content type: Research Published on:

  19. To compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brachytherapy and stereotactic radiotherapy (SBRT).

    Authors: Zhuo Chen, Bin Wang, Zhouxue Wu, Hua Xiao, Yang Yang, Junying Fan, Yingjiang Gu, Chuan Chen and Jingbo Wu
    Citation: Journal of Inflammation 2023 20:23
    Content type: Research Published on:

  20. Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling is one subset. This inflammatory response is heterogeneous with respect to the inducti...

    Authors: Caroline Lindblad, Susanne Neumann, Sólrún Kolbeinsdóttir, Vasilios Zachariadis, Eric P. Thelin, Martin Enge, Sebastian Thams, Lou Brundin and Mikael Svensson
    Citation: Journal of Inflammation 2023 20:22
    Content type: Research Published on:

  22. Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induced acute liver injury (APAP-ALI) and there are limited treatments for this condition. AT...

    Authors: Jennifer A. Cartwright, Joanna P. Simpson, Natalie Z. M. Homer and Adriano G. Rossi
    Citation: Journal of Inflammation 2023 20:20
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Inflammation 2023 20:27

  23. Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely affecting patients’ physical and mental health. Accumulating evidence indicated that the immu...

    Authors: Xiangsheng Zhang, Jiurong Cheng, Yingdong Deng, Caiyun Guo, Yu Cao, Suo Wang, Chenxi Zhou, Ziqiang Lin, Simin Tang and Jun Zhou
    Citation: Journal of Inflammation 2023 20:19
    Content type: Research Published on:

  24. To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysr...

    Authors: S. C. Bergkamp, M. J. Wahadat, A. Salah, T. W. Kuijpers, V. Smith, S. W. Tas, J. M. van den Berg, S. Kamphuis and D. Schonenberg-Meinema
    Citation: Journal of Inflammation 2023 20:18
    Content type: Review Published on:

  25. Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and deat...

    Authors: Yawen Wu, Shilin Wei, Xiangyang Wu, Yongnan Li and Xue Han
    Citation: Journal of Inflammation 2023 20:17
    Content type: Review Published on:

  26. Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therape...

    Authors: Yinjiaozhi Li, Ruoming Tan, Ranran Li, Rui Tian, Zhaojun Liu, Xiaoli Wang, Erzhen Chen, Tingting Pan and Hongping Qu
    Citation: Journal of Inflammation 2023 20:16
    Content type: Research Published on:

  27. The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC),...

    Authors: Fyyaz Siddiqui, Denis Gallagher, Hannah Shuster-Hyman, Lianet Lopez, Andrée Gauthier-Fisher and Clifford L Librach
    Citation: Journal of Inflammation 2023 20:15
    Content type: Research Published on:

  28. Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, there is no adequate therapeutic strategy to reverse the progression of OA. Many natural pl...

    Authors: Qing Ding, Ruizhuo Zhang, Gaohong Sheng, Tianqi Wang, Shaoze Jing, Tian Ma, Shanxi Wang, Hongqi Zhao, Hua Wu and Wenkai Li
    Citation: Journal of Inflammation 2023 20:14
    Content type: Research Published on:

  29. Acute lung injury (ALI) is a life-threatening condition that fundamentally results from inflammation and edema in the lung. There are no effective treatments available for clinical use. Previously, we found th...

    Authors: Yeomyeong Kim, Cho-Rong Bae, Dongyeop Kim, Hyejeong Kim, Sunghye Lee, Haiying Zhang, Minyoung Noh, Young-Myeong Kim, Naoki Mochizuki and Young-Guen Kwon
    Citation: Journal of Inflammation 2023 20:13
    Content type: Research Published on:

  30. Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation invo...

    Authors: Matti Hoch, Suchi Smita, Konstantin Cesnulevicius, Myron Schultz, David Lescheid, Olaf Wolkenhauer and Shailendra Gupta
    Citation: Journal of Inflammation 2023 20:12
    Content type: Research Published on:

  31. The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and...

    Authors: Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham…
    Citation: Journal of Inflammation 2023 20:11
    Content type: Review Published on:

  32. Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening res...

    Authors: Petra Kosutova, Pavol Mikolka, Daniela Mokra and Andrea Calkovska
    Citation: Journal of Inflammation 2023 20:10
    Content type: Research Published on:

  33. Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) ...

    Authors: Xinkun Cheng, Torsten Lowin, Nadine Honke and Georg Pongratz
    Citation: Journal of Inflammation 2023 20:9
    Content type: Research Published on:

  34. Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear Factor-κappa B (NF-κB) is a critical transcription factors family of the inflammatory pa...

    Authors: Jiali Gan, Lin Guo, Xiaolu Zhang, Qun Yu, Qiuyue Yang, Yilin Zhang, Wenyun Zeng, Xijuan Jiang and Maojuan Guo
    Citation: Journal of Inflammation 2023 20:8
    Content type: Review Published on:

  35. The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related a...

    Authors: Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen, Yi Liu, Yi Zhao and Martin Herrmann
    Citation: Journal of Inflammation 2023 20:7
    Content type: Research Published on:

  36. Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections....

    Authors: Sofia Malm Tillgren, Juan José Nieto-Fontarigo, Samuel Cerps, Sangeetha Ramu, Mandy Menzel, Irma Mahmutovic Persson, Anja Meissner, Hamid Akbarshahi and Lena Uller
    Citation: Journal of Inflammation 2023 20:6
    Content type: Research Published on:

  37. Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. T...

    Authors: Xinxin Zhang, Xingsheng Wang, Li Sun, Guangsheng Gao and Yun Li
    Citation: Journal of Inflammation 2023 20:5
    Content type: Research Published on:

  38. Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable option for treating these disorders. Previous work indicated pretreatment with beta-funalt...

    Authors: Stephanie Myers, Kelly McCracken, Daniel J. Buck, J. Thomas Curtis and Randall L. Davis
    Citation: Journal of Inflammation 2023 20:4
    Content type: Research Published on:

  40. Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellula...

    Authors: Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma and Qingrui Yang
    Citation: Journal of Inflammation 2023 20:2
    Content type: Review Published on:

  41. Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under physiological conditions are typ...

    Authors: Ali Saeedi-Boroujeni, Daryush Purrahman, Ali Shojaeian, Łukasz A. Poniatowski, Fatemeh Rafiee and Mohammad-Reza Mahmoudian-Sani
    Citation: Journal of Inflammation 2023 20:1
    Content type: Review Published on:

  42. Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein exp...

    Authors: Tapas Patra and Ranjit Ray
    Citation: Journal of Inflammation 2022 19:28
    Content type: Research Published on:

  43. Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternat...

    Authors: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo and Benedetta Cinque
    Citation: Journal of Inflammation 2022 19:27
    Content type: Research Published on:

  44. The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Although IL-17A/F...

    Authors: Anthony Altieri, Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Breann Recksiedler, Victor Spicer, Pieter S Hiemstra, Andrew J Halayko and Neeloffer Mookherjee
    Citation: Journal of Inflammation 2022 19:26
    Content type: Research Published on:

  45. Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed asthma– chronic obstructive pulmonary disease overlap (ACO). ACO is heterogeneous cond...

    Authors: Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An and Jung Hur
    Citation: Journal of Inflammation 2022 19:25
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Inflammation 2023 20:3

  46. Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is...

    Authors: Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li and Beixian Zhou
    Citation: Journal of Inflammation 2022 19:24
    Content type: Research Published on:

  47. The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflammation and liver failure in sepsis. Neutrophils have the highest CXCR2 expression in mi...

    Authors: Na Liu, Michael Bauer and Adrian T. Press
    Citation: Journal of Inflammation 2022 19:23
    Content type: Review Published on:

  48. The behavior of neutrophils is very important for the resolution of inflammation and tissue repair. People have used advanced imaging techniques to observe the phenomenon of neutrophils leaving the injured or ...

    Authors: Qichao Xu, Wenqi Zhao, Mingyang Yan and Hongxia Mei
    Citation: Journal of Inflammation 2022 19:22
    Content type: Review Published on:

  49. Obesity and insulin resistance (IR), the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation. Bariatric surgery leads to a considerable reduction in the a...

    Authors: Sara Coletta, Elisabetta Trevellin, Marisa Benagiano, Jacopo Romagnoli, Chiara Della Bella, Mario Milco D’Elios, Roberto Vettor and Marina de Bernard
    Citation: Journal of Inflammation 2022 19:21
    Content type: Brief Report Published on:

  50. Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflamm...

    Authors: Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E. Van Eyk and Justyna Fert-Bober
    Citation: Journal of Inflammation 2022 19:20
    Content type: Research Published on:

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Journal of Inflammation

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