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  1. Congestive heart failure (CHF) is a major cause of the development of progressive chronic kidney disease (CKD), while the mechanism is still unknown. LncRNA PVT1 contributes to kidney injury. This study aimed ...

    Authors: Yingwei Chang, Chunmei Liu, Jing Wang, Jing Feng, Yulan Chen, Mufang Qi and Yaguang Guo

    Citation: Journal of Inflammation 2021 18:27

    Content type: Research

    Published on:

  2. Chronic periodontitis is associated with an increased risk for systemic conditions such as cardiovascular disease, diabetes, and osteoporosis. During chronic periodontitis, endotoxin (lipopolysaccharide, LPS) ...

    Authors: Ying Gu, Veena Raja, Hsi-Ming Lee, Houlin Hong, Glenn Prestwich and Maria E. Ryan

    Citation: Journal of Inflammation 2021 18:26

    Content type: Research

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  3. Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathogenesis and treatment of acute kidney injury (AKI) is of great signific...

    Authors: Fei Gao, Mingjiang Qian, Guoyue Liu, Wanping Ao, Dahua Dai and Cunzhi Yin

    Citation: Journal of Inflammation 2021 18:25

    Content type: Research

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  4. Acute tonsillitis represents one of the most frequent reasons patients seek primary medical care and otorhinolaryngology consultation. Therefore, recurrent episodes of acute tonsillitis (RAT), also called chro...

    Authors: Christoph Spiekermann, Alicia Seethaler, Annika McNally, Markus Stenner, Claudia Rudack, Johannes Roth and Thomas Vogl

    Citation: Journal of Inflammation 2021 18:24

    Content type: Research

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  5. It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD). However, only a limited number of ICD-in...

    Authors: Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu and Qing An

    Citation: Journal of Inflammation 2021 18:23

    Content type: Research

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  6. Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabil...

    Authors: Hsin-Hui Hsieh, Yen-An Chen, Yao-Jen Chang, Hsin-Hui Wang, Ya-Han Yu, Sheng-Wei Lin, Yin-Jung Huang, Steven Lin and Ching-Jin Chang

    Citation: Journal of Inflammation 2021 18:22

    Content type: Research

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  7. Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted inflammatory factors have an association with the outcome of inflammation. Luteolin, a flavonoid a...

    Authors: Shuxia Wang, Shuhang Xu, Jing Zhou, Li Zhang, Xiaodong Mao, Xiaoming Yao and Chao Liu

    Citation: Journal of Inflammation 2021 18:21

    Content type: Research

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  8. Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj...

    Authors: Xiao-Xia Gu, Xiao-Xia Xu, Hui-Hua Liao, Ruo-Na Wu, Wei-Ming Huang, Li-Xia Cheng, Yi-Wen Lu and Jian Mo

    Citation: Journal of Inflammation 2021 18:20

    Content type: Research

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  9. The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke.

    Authors: Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant and Sandra J. Hodge

    Citation: Journal of Inflammation 2021 18:19

    Content type: Research

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  10. Anti-vascular endothelial growth factor (VEGF) has been used as a therapeutic drug for the treatment of some human diseases. However, no systematic evidence is performed for assessing the role of VEGF in perio...

    Authors: Bo Ren, Que Feng, Shan He, Yanfeng Li, Jiadong Fan, Guangquan Chai, Le Liu, Haiyun Liu, Chunhao Yang, Yingdi Wang, Huihui Liu, Huanyue Liu and Yafan Song

    Citation: Journal of Inflammation 2021 18:18

    Content type: Research

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  11. Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injur...

    Authors: Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas and Yohannes T. Ghebre

    Citation: Journal of Inflammation 2021 18:17

    Content type: Research

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  12. The differences between adults and children in inflammatory bowel disease (IBD) phenotype, severity, complications, co-morbidities, and response to the therapy resulted in the extraction of paediatric IBD. It ...

    Authors: Paulina Krawiec, Agnieszka Pawłowska-Kamieniak and Elżbieta Pac-Kożuchowska

    Citation: Journal of Inflammation 2021 18:13

    Content type: Review

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  13. Acute kidney injury (AKI) results from renal dysfunction caused by various causes, resulting in high mortality. The underlying mechanisms of ischemia-reperfusion (I/R) induced AKI is very complicated and neede...

    Authors: Li Chen, Jun-Ying Xu and Hong-Bao Tan

    Citation: Journal of Inflammation 2021 18:12

    Content type: Research

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  14. Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA...

    Authors: Aysan Eslami Abriz, Reza Rahbarghazi, Alireza Nourazarian, Çıgır Biray Avci, Soltan Ali Mahboob, Maryam Rahnema, Atefeh Araghi and Morteza Heidarzadeh

    Citation: Journal of Inflammation 2021 18:10

    Content type: Research

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  15. TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transd...

    Authors: Shudong Liu, Jie Wang, Wenyan Li, Hui Shi, Changlong Zhou, Ge Tang, Jiangwei Zhang and Zhao Yang

    Citation: Journal of Inflammation 2021 18:9

    Content type: Research

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  16. Sepsis is a complex syndrome characterized by a dysregulated inflammatory response to systemic infection and leads to shock, multiple organ failure and death especially if not recognized early and treated prom...

    Authors: Wei Wang, Rong-Li Xu, Ping He and Rui Chen

    Citation: Journal of Inflammation 2021 18:8

    Content type: Research

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  17. Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical role in AKI and subsequent kidney repair through the regulation of vario...

    Authors: Chong Huang, Yan Chen, Bin Lai, Yan-Xia Chen, Cheng-Yun Xu and Yuan-Fei Liu

    Citation: Journal of Inflammation 2021 18:7

    Content type: Research

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  18. Intervertebral disk degeneration (IVDD) contributes to low back pain. Increased cell apoptosis and inflammation, decreased extracellular matrix are associated with IVDD. Nuclear factor-kappa B (NF-κB) signalin...

    Authors: Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo and Zhongxu Cai

    Citation: Journal of Inflammation 2021 18:6

    Content type: Research

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  19. Obesity is an epidemic disease in the world, the treatment and prevention of obesity methods have gained great attention. Lactobacillus is the main member of probiotics, and the physiological activity of it is...

    Authors: Ya Wu, Xueya Li, Fang Tan, Xianrong Zhou, Jianfei Mu and Xin Zhao

    Citation: Journal of Inflammation 2021 18:5

    Content type: Research

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  20. Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of a...

    Authors: Afshin Rahbarghazi, Marefat Siahkouhian, Reza Rahbarghazi, Mahdi Ahmadi, Lotfali Bolboli, Rana Keyhanmanesh, Mahdi Mahdipour and Hadi Rajabi

    Citation: Journal of Inflammation 2021 18:4

    Content type: Review

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  21. SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible f...

    Authors: Ali Saeedi-Boroujeni and Mohammad-Reza Mahmoudian-Sani

    Citation: Journal of Inflammation 2021 18:3

    Content type: Hypothesis

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  22. NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which ...

    Authors: Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Takahiko Tsukuda, Masataka Katakami, Toshio Ariyasu, Shimpei Ushio and Kanso Iwaki

    Citation: Journal of Inflammation 2021 18:2

    Content type: Research

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  23. Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved ef...

    Authors: Fang Cui, Jing Guo, Hao-Fei Hu, Yi Zhang and Min Shi

    Citation: Journal of Inflammation 2020 17:36

    Content type: Research

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  24. Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic comp...

    Authors: Karina Vargas-Sánchez, Laura Vargas, Yenny Urrutia, Iván Beltrán, Ana Beatriz Rossi, Hernán Yupanqui Lozano, Jorge Guarín and Monica Losada-Barragán

    Citation: Journal of Inflammation 2020 17:35

    Content type: Research

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  25. Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functi...

    Authors: James G. Macfarlane, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi and A. John Simpson

    Citation: Journal of Inflammation 2020 17:34

    Content type: Research

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  26. HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatm...

    Authors: Mariana del Rocio Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Sarah Ratkovich-González, Karina Sánchez-Reyes, Luz A. González-Hernández, Jaime F. Andrade-Villanueva and Monserrat Alvarez-Zavala

    Citation: Journal of Inflammation 2020 17:32

    Content type: Research

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  27. Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) relat...

    Authors: Tao Liu, Jingbin Liu, Chunhua Tian, Hongyuan Wang, Min Wen and Mingyu Yan

    Citation: Journal of Inflammation 2020 17:31

    Content type: Research

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  28. Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the thera...

    Authors: Shi-Jian Yi, Yang Wu, Lan-Lan Li, Qian-Kun Liang and Yue Xiao

    Citation: Journal of Inflammation 2020 17:30

    Content type: Research

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  29. Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and includ...

    Authors: Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch…

    Citation: Journal of Inflammation 2020 17:29

    Content type: Research

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  30. Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL defi...

    Authors: Sofie Jacobson, Peter Larsson, Anna-Maja Åberg, Göran Johansson, Ola Winsö and Stefan Söderberg

    Citation: Journal of Inflammation 2020 17:28

    Content type: Research

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  31. Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion rep...

    Authors: Ludmila Khailova, Justin Robison, James Jaggers, Richard Ing, Scott Lawson, Amy Treece, Danielle Soranno, Suzanne Osorio Lujan and Jesse A. Davidson

    Citation: Journal of Inflammation 2020 17:27

    Content type: Research

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  32. Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that l...

    Authors: Hongxia Mei, Ying Tao, Tianhao Zhang and Feng Qi

    Citation: Journal of Inflammation 2020 17:26

    Content type: Research

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  33. NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactiv...

    Authors: Fenglian He, Guanghui Zheng, Jingying Hou, Qiaohua Hu, Qin Ling, Gongfa Wu, Hui Zhao, Jin Yang, Yue Wang, Longyuan Jiang, Wanchun Tang and Zhengfei Yang

    Citation: Journal of Inflammation 2020 17:25

    Content type: Research

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  34. Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ...

    Authors: Baoming Wang, Yik Lung Chan, Shengyu Zhou, Sonia Saad, Hui Chen and Brian G Oliver

    Citation: Journal of Inflammation 2020 17:24

    Content type: Research

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  35. Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor microenvironment enables specific and efficient metastasis, weakens immunological monitoring, and mediates drug resistance. Tum...

    Authors: Ying Feng, Meizhu Xiao, Zihan Zhang, Ran Cui, Xuan Jiang, Shuzhen Wang, Huimin Bai, Chongdong Liu and Zhenyu Zhang

    Citation: Journal of Inflammation 2020 17:23

    Content type: Hypothesis

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  36. Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas...

    Authors: Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong and Heeyeong Cho

    Citation: Journal of Inflammation 2020 17:20

    Content type: Research

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  37. To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia.

    Authors: Rongmeng Jiang, Bing Han, Meihua Song, Bing Xue, Yongxiang Zhang, Yanyan Ding, Jin Chen, Jing Zhu, Jianhua Liu, Qingrong Nie, Xuefeng Han, Xiuhong Jin, Xiaoyin Shan, Weian Guo, Erming Zhang, Zuoqing Zhang…

    Citation: Journal of Inflammation 2020 17:19

    Content type: Research

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  38. Dexmedetomidine (Dex) is a highly selective agonist of the α2 adrenergic receptor and a common sedative; however, its anti-inflammatory effect has been studied. In this study, the inhibitory effect of Dex on i...

    Authors: Gang Lv, Guanhua Zhu, Maohua Xu, Xingping Gao and Qingfeng Xiao

    Citation: Journal of Inflammation 2020 17:18

    Content type: Research

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  39. Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo...

    Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Qijiang Xiong, Ling Yang, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:17

    Content type: Research

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  40. Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enha...

    Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons and Sandra Hodge

    Citation: Journal of Inflammation 2020 17:16

    Content type: Research

    Published on:

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