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  1. Research

    LPS regulates the expression of glucocorticoid receptor α and β isoforms and induces a selective glucocorticoid resistance in vitro

    This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vi...

    Maria Luisa Molina, Julia Guerrero, John A. Cidlowski, Héctor Gatica and Annelise Goecke

    Journal of Inflammation 2017 14:22

    Published on: 16 October 2017

  2. Research

    Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice

    The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced p...

    Tetsuya Yokoyama, Toyoshi Yanagihara, Kunihiro Suzuki, Naoki Hamada, Kazuya Tsubouchi, Saiko Ogata-Suetsugu, Hironori Mikumo, Chika Ikeda-Harada, Takashige Maeyama, Kazuyoshi Kuwano and Yoichi Nakanishi

    Journal of Inflammation 2017 14:20

    Published on: 18 September 2017

  3. Short Report

    Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

    In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, us...

    Torbjörn Karlsson

    Journal of Inflammation 2017 14:21

    Published on: 18 September 2017

  4. Research

    Leptin independently predicts development of sepsis and its outcome

    Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be invol...

    Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö and Stefan Söderberg

    Journal of Inflammation 2017 14:19

    Published on: 11 September 2017

  5. Research

    Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling

    Previous studies have demonstrated that ovalbumin sensitization promotes chronic asthma phenotype in murine asthma model. Human mesenchymal stem cells (hMSCs) are multipotent cells in vitro that have been show...

    Benjamin D. Goldstein, Mark E. Lauer, Arnold I. Caplan and Tracey L. Bonfield

    Journal of Inflammation 2017 14:18

    Published on: 30 August 2017

  6. Review

    Interleukin-35 on B cell and T cell induction and regulation

    Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transd...

    Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang and Ke Jiang

    Journal of Inflammation 2017 14:16

    Published on: 7 August 2017

  7. Research

    Resveratrol protects against ICV collagenase-induced neurobehavioral and biochemical deficits

    Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary c...

    Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra and Anurag Kuhad

    Journal of Inflammation 2017 14:14

    Published on: 9 June 2017

  8. Review

    Regulating STING in health and disease

    The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INte...

    Yang Li, Heather L. Wilson and Endre Kiss-Toth

    Journal of Inflammation 2017 14:11

    Published on: 7 June 2017

  9. Short Report

    Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle

    Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We pre...

    Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha and Rina Yu

    Journal of Inflammation 2017 14:9

    Published on: 11 May 2017

  10. Research

    Successful reduction of inflammatory responses and arachidonic acid–cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein

    Adipocyte fatty acid-binding protein, also known as aP2 or fatty acid-binding protein 4 (FABP4), plays an important role in inflammatory and metabolic responses in adipocytes and macrophages. Recent work has d...

    Qian Wang, Guanglin Shi, Ying Teng, Xia Li, Jin Xie, Qin Shen, Caixin Zhang, Songshi Ni and Zhiyuan Tang

    Journal of Inflammation 2017 14:8

    Published on: 20 March 2017

  11. Research

    Overexpression of aquaporin 4 in articular chondrocytes exacerbates the severity of adjuvant-induced arthritis in rats: an in vivo and in vitro study

    The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression of a...

    Li Cai, Chao Lei, Rong Li, Wei-na Chen, Cheng-mu Hu, Xiao-yu Chen and Chun-mei Li

    Journal of Inflammation 2017 14:6

    Published on: 1 March 2017

  12. Research

    Influence of vaginal lactoferrin administration on amniotic fluid cytokines and its role against inflammatory complications of pregnancy

    An altered amniotic cytokine profile has been reported in inflammatory pregnancy complications with a leading role for IL-6, a marker of the foetal systemic inflammatory response. Up to this date there is no e...

    Martina Maritati, Manola Comar, Nunzia Zanotta, Silva Seraceni, Alessandro Trentini, Fabrizio Corazza, Fortunato Vesce and Carlo Contini

    Journal of Inflammation 2017 14:5

    Published on: 15 February 2017

  13. Research

    Ezetimibe reduces cholesterol content and NF-kappaB activation in liver but not in intestinal tissue in guinea pigs

    Statins (HMG CoA reductase inhibitors), in addition to reducing circulating cholesterol and incidence of coronary heart disease, also have pleiotropic, anti-inflammatory effects. Patients with chronic liver di...

    Peter Fraunberger, Elisabeth Gröne, Hermann-Josef Gröne, Heinz Drexel and Autar K. Walli

    Journal of Inflammation 2017 14:3

    Published on: 2 February 2017

  14. Research

    Effects of corticosteroid plus long-acting beta2-agonist on the expression of PD-L1 in double-stranded RNA-induced lung inflammation in mice

    Airway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of vir...

    Saaka Hamano, Koichiro Matsumoto, Ken Tonai, Satoru Fukuyama, Keiko Kan-o, Nanae Seki, Hiromasa Inoue and Yoichi Nakanishi

    Journal of Inflammation 2017 14:2

    Published on: 17 January 2017

  15. Research

    Cardiovascular diseases-related GNB3 C825T polymorphism has a significant sex-specific effect on serum soluble E-selectin levels

    The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular e...

    Kokoè Mélinda Gbadoe, Nazha Berdouzi, Alex-Ander Aldasoro Aguiñano, Ndeye Coumba Ndiaye and Sophie Visvikis-Siest

    Journal of Inflammation 2016 13:39

    Published on: 9 December 2016

  16. Research

    Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation

    The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2 diabetes (T2D). While TLR2/4 expression changes asso...

    Rasheed Ahmad, Shihab Kochumon, Reeby Thomas, Valerie Atizado and Sardar Sindhu

    Journal of Inflammation 2016 13:38

    Published on: 8 December 2016

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Affiliated with the British Inflammation Research Association (BIRAs).