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Editors' Pick: SARS-CoV-2 COVID-19 Susceptibility and Lung Inflammatory Storms by Smoking and Vaping

Aging, smoking/vaping results in severe disease outcome and mortality amongst COVID-19 patients. SARS-CoV-2 with a membrane spike glycoprotein furin along with its receptor ACE2 and TMPRSS2 protease are increased by smoking/vaping in lung epithelium rendering viral entry and augmented infection. This results in a ‘cytokine storm’ involving excessive production of pro-inflammatory cytokines/chemokines. This review therefore discusses the impact of smoking /vaping on the key inflammatory mechanisms following Covid-19 infection and the possible therapeutic strategies required to overcome this excessive inflammatory response.

COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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Aims and scope

Journal of Inflammation is an open access, peer-reviewed online journal publishing articles on all aspects of research into inflammation. Non-research articles are specially commissioned by the Editors-in-Chief. 

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Announcing the launch of In Review

Journal of Inflammation, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:

  • Share their work with fellow researchers to read, comment on, and cite even before publication
  • Showcase their work to funders and others with a citable DOI while it is still under review
  • Track their manuscript - including seeing when reviewers are invited, and when reports are received 

Submit your review

Journal of Inflammation welcomes review articles on a variety of different topics relating to the scope of the journal. Submit your review today.

For further queries or to discuss the limited funds which may be available to cover the article-processing charge, please contact the editorial team.

Editor profiles

Prof Paul Kirkham, Editor-in-Chief

Prof Kirkham is Professor of Cell Biology at the University of Wolverhampton and a fellow of the HEA. His research interests focus on understanding the mechanisms of disease pathogenesis driven by oxidative stress and its impact on cell function and inflammation, particularly in relation to respiratory disease.

Prof Adriano Rossi, Editor-in-Chief

Prof Rossi holds the position of Personal Chair in Respiratory and Inflammation Pharmacology at the University of Edinburgh. Prof Rossi is a Fellow of the Society of Biology and a Fellow of the British Pharmacological Society. His research involves investigating the cellular processes and signalling mechanisms controlling inflammation with a focus on understanding inflammation resolution.

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Affiliated with the British Inflammation Research Association (BIRAs).

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