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Editors' Pick: SARS-CoV-2 COVID-19 Susceptibility and Lung Inflammatory Storms by Smoking and Vaping
Aging, smoking/vaping results in severe disease outcome and mortality amongst COVID-19 patients. SARS-CoV-2 with a membrane spike glycoprotein furin along with its receptor ACE2 and TMPRSS2 protease are increased by smoking/vaping in lung epithelium rendering viral entry and augmented infection. This results in a ‘cytokine storm’ involving excessive production of pro-inflammatory cytokines/chemokines. This review therefore discusses the impact of smoking /vaping on the key inflammatory mechanisms following Covid-19 infection and the possible therapeutic strategies required to overcome this excessive inflammatory response.
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Aims and scope
Journal of Inflammation is an open access, peer-reviewed online journal publishing articles on all aspects of research into inflammation. Non-research articles are specially commissioned by the Editors-in-Chief.
Announcing the launch of In Review
Journal of Inflammation, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:
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Prof Kirkham is Professor of Cell Biology at the University of Wolverhampton and a fellow of the HEA. His research interests focus on understanding the mechanisms of disease pathogenesis driven by oxidative stress and its impact on cell function and inflammation, particularly in relation to respiratory disease.
Prof Rossi holds the position of Personal Chair in Respiratory and Inflammation Pharmacology at the University of Edinburgh. Prof Rossi is a Fellow of the Society of Biology and a Fellow of the British Pharmacological Society. His research involves investigating the cellular processes and signalling mechanisms controlling inflammation with a focus on understanding inflammation resolution.
Affiliated with the British Inflammation Research Association (BIRAs).
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20 days to first decision for all manuscripts (Median)
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