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  1. Content type: Research

    There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnor...

    Authors: Tianrun Huang, Guangchun Wang, Yangyang Hu, Heng Shi, Keyi Wang, Lei Yin and Bo Peng

    Citation: Journal of Inflammation 2019 16:20

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  2. Content type: Research

    Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising...

    Authors: Yinghai Jiang, Jing Wang, Haiqin Li and Lingjie Xia

    Citation: Journal of Inflammation 2019 16:19

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  3. Content type: Research

    Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to ...

    Authors: Paulo R. Z. Antas, Carlos G. G. Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Thaíze Pedro, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, Luíz R. R. Castello-Branco and Rosa T. Pinho

    Citation: Journal of Inflammation 2019 16:18

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  4. Content type: Research

    Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) ...

    Authors: Chu-Sook Kim, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Jeong Woo Park, Hun Taeg Chung, Eun Roh, Min-Seon Kim, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2019 16:17

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  5. Content type: Research

    Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hy...

    Authors: Rosangela Nascimento Pimentel, Ricardo Costa Petroni, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Mariana Macedo Andrade, Suely Kumini Ariga and Francisco Garcia Soriano

    Citation: Journal of Inflammation 2019 16:16

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  6. Content type: Review

    The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves th...

    Authors: Paulina Niedźwiedzka-Rystwej, Weronika Repka, Beata Tokarz-Deptuła and Wiesław Deptuła

    Citation: Journal of Inflammation 2019 16:15

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  7. Content type: Research

    Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t...

    Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, Jürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf

    Citation: Journal of Inflammation 2019 16:14

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  8. Content type: Research

    Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for...

    Authors: Qihong Que, Xinghua Guo, Longxin Zhan, Shaodong Chen, Zengli Zhang, Xiaoming Ni, Bin Ye and Shuanglin Wan

    Citation: Journal of Inflammation 2019 16:13

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  9. Content type: Short Report

    Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem...

    Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard W. Moyer…

    Citation: Journal of Inflammation 2019 16:12

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  10. Content type: Research

    Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the...

    Authors: Xuan Li, Lijie Duan, Sujuan Yuan, Xibing Zhuang, Tiankui Qiao and Jian He

    Citation: Journal of Inflammation 2019 16:11

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  11. Content type: Review

    There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I...

    Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase

    Citation: Journal of Inflammation 2019 16:10

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  12. Content type: Research

    Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest...

    Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura

    Citation: Journal of Inflammation 2019 16:9

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  13. Content type: Review

    Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga...

    Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi

    Citation: Journal of Inflammation 2019 16:8

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  14. Content type: Research

    Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of...

    Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee

    Citation: Journal of Inflammation 2019 16:7

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  15. Content type: Research

    Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren’s syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le...

    Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon

    Citation: Journal of Inflammation 2019 16:6

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  16. Content type: Research

    Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ...

    Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson

    Citation: Journal of Inflammation 2019 16:5

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  17. Content type: Research

    Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei...

    Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka

    Citation: Journal of Inflammation 2019 16:4

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  18. Content type: Research

    Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ...

    Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang

    Citation: Journal of Inflammation 2019 16:3

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  19. Content type: Research

    In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification...

    Authors: Sandra Pérez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo

    Citation: Journal of Inflammation 2019 16:2

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  20. Content type: Review

    Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o...

    Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta

    Citation: Journal of Inflammation 2019 16:1

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  22. Content type: Research

    Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ...

    Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao

    Citation: Journal of Inflammation 2018 15:27

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  23. Content type: Research

    Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ...

    Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura

    Citation: Journal of Inflammation 2018 15:26

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  24. Content type: Research

    The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r...

    Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan

    Citation: Journal of Inflammation 2018 15:25

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  25. Content type: Research

    Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo...

    Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda

    Citation: Journal of Inflammation 2018 15:24

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  26. Content type: Research

    Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer’s d...

    Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2018 15:23

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  28. Content type: Research

    High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate...

    Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen

    Citation: Journal of Inflammation 2018 15:21

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  29. Content type: Research

    Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul...

    Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz

    Citation: Journal of Inflammation 2018 15:20

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  30. Content type: Research

    Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin...

    Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin

    Citation: Journal of Inflammation 2018 15:19

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  31. Content type: Research

    Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab...

    Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker

    Citation: Journal of Inflammation 2018 15:18

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  33. Content type: Research

    The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as...

    Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang

    Citation: Journal of Inflammation 2018 15:16

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  34. Content type: Research

    T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies ind...

    Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang and Xu D. Xiang

    Citation: Journal of Inflammation 2018 15:15

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  35. Content type: Research

    Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperi...

    Authors: Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao and Mingzhi Gong

    Citation: Journal of Inflammation 2018 15:14

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  36. Content type: Research

    The CARD family plays an important role in innate immune response by the activation of NF-κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some me...

    Authors: Jesús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez and Montserrat A. Lara-Velazquez

    Citation: Journal of Inflammation 2018 15:13

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  37. Content type: Research

    Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2...

    Authors: Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede and Tobias Hilbert

    Citation: Journal of Inflammation 2018 15:12

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  38. Content type: Research

    Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant...

    Authors: Diego A. Vicente, Matthew J. Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A. Elster and Thomas A. Davis

    Citation: Journal of Inflammation 2018 15:11

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  39. Content type: Research

    Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors imp...

    Authors: Christian Patry, Daniela Stamm, Christian Betzen, Burkhard Tönshoff, Benito A. Yard, Grietje Ch. Beck and Neysan Rafat

    Citation: Journal of Inflammation 2018 15:10

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  41. Content type: Research

    Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. T...

    Authors: K. L. C. da Silva, A. P. Camacho, F. C. Mittestainer, B. M. Carvalho, A. Santos, D. Guadagnini, A. G. Oliveira and M. J. A. Saad

    Citation: Journal of Inflammation 2018 15:8

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  42. Content type: Research

    Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiolog...

    Authors: Chunyan Lou and Yanyang Li

    Citation: Journal of Inflammation 2018 15:7

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  43. Content type: Correction

    Upon publication of the original article [1] it was highlighted by the authors that the first affiliation of author Haiyan Yin was incorrectly cited in duplicate as “Department of Neurology, Affiliated Hospita...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan

    Citation: Journal of Inflammation 2018 15:6

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    The original article was published in Journal of Inflammation 2017 14:17

  44. Content type: Research

    Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im...

    Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock

    Citation: Journal of Inflammation 2018 15:5

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  45. Content type: Research

    Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ...

    Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang

    Citation: Journal of Inflammation 2018 15:4

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  46. Content type: Research

    Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve...

    Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin

    Citation: Journal of Inflammation 2018 15:3

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  47. Content type: Research

    In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel...

    Authors: T. Smith, L. Engelbrecht and C. Smith

    Citation: Journal of Inflammation 2018 15:2

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  48. Content type: Research

    Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis...

    Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye

    Citation: Journal of Inflammation 2018 15:1

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  50. Content type: Research

    An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust eff...

    Authors: David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek and Sharath Hegde

    Citation: Journal of Inflammation 2017 14:28

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