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  1. NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which ...

    Authors: Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Takahiko Tsukuda, Masataka Katakami, Toshio Ariyasu, Shimpei Ushio and Kanso Iwaki

    Citation: Journal of Inflammation 2021 18:2

    Content type: Research

    Published on:

  3. Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved ef...

    Authors: Fang Cui, Jing Guo, Hao-Fei Hu, Yi Zhang and Min Shi

    Citation: Journal of Inflammation 2020 17:36

    Content type: Research

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  4. Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic comp...

    Authors: Karina Vargas-Sánchez, Laura Vargas, Yenny Urrutia, Iván Beltrán, Ana Beatriz Rossi, Hernán Yupanqui Lozano, Jorge Guarín and Monica Losada-Barragán

    Citation: Journal of Inflammation 2020 17:35

    Content type: Research

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  5. Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functi...

    Authors: James G. Macfarlane, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi and A. John Simpson

    Citation: Journal of Inflammation 2020 17:34

    Content type: Research

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  7. HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatm...

    Authors: Mariana del Rocio Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Sarah Ratkovich-González, Karina Sánchez-Reyes, Luz A. González-Hernández, Jaime F. Andrade-Villanueva and Monserrat Alvarez-Zavala

    Citation: Journal of Inflammation 2020 17:32

    Content type: Research

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  8. Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) relat...

    Authors: Tao Liu, Jingbin Liu, Chunhua Tian, Hongyuan Wang, Min Wen and Mingyu Yan

    Citation: Journal of Inflammation 2020 17:31

    Content type: Research

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  9. Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the thera...

    Authors: Shi-Jian Yi, Yang Wu, Lan-Lan Li, Qian-Kun Liang and Yue Xiao

    Citation: Journal of Inflammation 2020 17:30

    Content type: Research

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  10. Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and includ...

    Authors: Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch…

    Citation: Journal of Inflammation 2020 17:29

    Content type: Research

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  11. Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL defi...

    Authors: Sofie Jacobson, Peter Larsson, Anna-Maja Åberg, Göran Johansson, Ola Winsö and Stefan Söderberg

    Citation: Journal of Inflammation 2020 17:28

    Content type: Research

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  12. Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion rep...

    Authors: Ludmila Khailova, Justin Robison, James Jaggers, Richard Ing, Scott Lawson, Amy Treece, Danielle Soranno, Suzanne Osorio Lujan and Jesse A. Davidson

    Citation: Journal of Inflammation 2020 17:27

    Content type: Research

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  13. Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that l...

    Authors: Hongxia Mei, Ying Tao, Tianhao Zhang and Feng Qi

    Citation: Journal of Inflammation 2020 17:26

    Content type: Research

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  14. NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactiv...

    Authors: Fenglian He, Guanghui Zheng, Jingying Hou, Qiaohua Hu, Qin Ling, Gongfa Wu, Hui Zhao, Jin Yang, Yue Wang, Longyuan Jiang, Wanchun Tang and Zhengfei Yang

    Citation: Journal of Inflammation 2020 17:25

    Content type: Research

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  15. Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ...

    Authors: Baoming Wang, Yik Lung Chan, Shengyu Zhou, Sonia Saad, Hui Chen and Brian G Oliver

    Citation: Journal of Inflammation 2020 17:24

    Content type: Research

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  16. Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor microenvironment enables specific and efficient metastasis, weakens immunological monitoring, and mediates drug resistance. Tum...

    Authors: Ying Feng, Meizhu Xiao, Zihan Zhang, Ran Cui, Xuan Jiang, Shuzhen Wang, Huimin Bai, Chongdong Liu and Zhenyu Zhang

    Citation: Journal of Inflammation 2020 17:23

    Content type: Hypothesis

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  19. Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas...

    Authors: Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong and Heeyeong Cho

    Citation: Journal of Inflammation 2020 17:20

    Content type: Research

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  20. To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia.

    Authors: Rongmeng Jiang, Bing Han, Meihua Song, Bing Xue, Yongxiang Zhang, Yanyan Ding, Jin Chen, Jing Zhu, Jianhua Liu, Qingrong Nie, Xuefeng Han, Xiuhong Jin, Xiaoyin Shan, Weian Guo, Erming Zhang, Zuoqing Zhang…

    Citation: Journal of Inflammation 2020 17:19

    Content type: Research

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  21. Dexmedetomidine (Dex) is a highly selective agonist of the α2 adrenergic receptor and a common sedative; however, its anti-inflammatory effect has been studied. In this study, the inhibitory effect of Dex on i...

    Authors: Gang Lv, Guanhua Zhu, Maohua Xu, Xingping Gao and Qingfeng Xiao

    Citation: Journal of Inflammation 2020 17:18

    Content type: Research

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  22. Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo...

    Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Qijiang Xiong, Ling Yang, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:17

    Content type: Research

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  23. Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enha...

    Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons and Sandra Hodge

    Citation: Journal of Inflammation 2020 17:16

    Content type: Research

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  25. Chronic inflammation is involved in the initiation and progression of various cancers, including liver cancer. The current study focuses on the characterization of the peripheral immune response in hepatocellu...

    Authors: C. Martín-Sierra, R. Martins, M. Coucelo, A. M. Abrantes, R. C. Oliveira, J. G. Tralhão, M. F. Botelho, E. Furtado, M. R. Domingues, A. Paiva and P. Laranjeira

    Citation: Journal of Inflammation 2020 17:14

    Content type: Research

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  26. Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol...

    Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan

    Citation: Journal of Inflammation 2020 17:13

    Content type: Research

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  27. Inflammatory molecular signals are modulated by a variety of intracellular transduction pathways, the activation of which may induce and amplify the spread of inflammatory response. Suppresser of cytokine sign...

    Authors: Na Meng, Ning-Ning Ji, Ziming Zhou, Yicheng Qian, Yu Tang, Kangbo Yang, Binbin Chen and Yong-Mei Zhang

    Citation: Journal of Inflammation 2020 17:12

    Content type: Research

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  28. Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antig...

    Authors: Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:10

    Content type: Research

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  29. The antisense cerebellar degenerative-related protein-1 (CDR1as) has been identified as a sponge for several microRNAs. MiR-641 has been shown to be downregulated in osteoarthritic human chondrocytes, but its ...

    Authors: Wei Zhang, Chi Zhang, Chengfang Hu, Congfeng Luo, Biao Zhong and Xiaowei Yu

    Citation: Journal of Inflammation 2020 17:8

    Content type: Research

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  30. Therapeutic potential of low-intensity ultrasound (LIUS) has become evident in various musculoskeletal diseases. We have previously shown that LIUS has an inhibitory effect on local edema in various diseases i...

    Authors: Kil Hwan Kim, Hyeon-Woo Im, Mrigendra Bir Karmacharya, Sejong Kim, Byoung-Hyun Min, So Ra Park and Byung Hyune Choi

    Citation: Journal of Inflammation 2020 17:7

    Content type: Research

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  31. The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination i...

    Authors: Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri and Yunes Panahi

    Citation: Journal of Inflammation 2020 17:6

    Content type: Review

    Published on:

  32. There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. Thi...

    Authors: Xu Li, Lu Li, Yuequan Shi, Sihan Yu and Xiaochun Ma

    Citation: Journal of Inflammation 2020 17:5

    Content type: Research

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  33. Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeut...

    Authors: Wenzhan Tu, Xiaolong Chen, Qiaoyun Wu, Xinwang Ying, Rong He, Xinfa Lou, Guanhu Yang, Kecheng Zhou and Songhe Jiang

    Citation: Journal of Inflammation 2020 17:4

    Content type: Research

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  34. Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen ...

    Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Guibo Feng, Qijiang Xiong, Ling Yang and Zhao Yang

    Citation: Journal of Inflammation 2020 17:3

    Content type: Research

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  35. The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was...

    Authors: Guang-chun Wang, Tian-run Huang, Yang-yang Hu, Ke-yi Wang, Heng Shi, Lei Yin and Bo Peng

    Citation: Journal of Inflammation 2020 17:2

    Content type: Research

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  38. Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies ...

    Authors: Elham Shahriyari, Leila Vahedi, Nasrin Roshanipour, Mohammad Asghari Jafarabadi, Amin Khamaneh and Maryam Ghaffari Laleh

    Citation: Journal of Inflammation 2019 16:26

    Content type: Research

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  39. Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors.

    Authors: Miguel Hueso, Angela Casas, Adrian Mallén, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras and Estanislao Navarro

    Citation: Journal of Inflammation 2019 16:25

    Content type: Research

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  40. Neuregulin receptor degradation protein-1 (Nrdp1) is an E3 ubiquitin ligase that plays an important role in regulating cell growth, apoptosis and oxidative stress. However, the data regarding its expression an...

    Authors: Changlong Zhou, Qingjun Liu, Wang Zhao, Ling Yang, Zhongyan Huang and Zhao Yang

    Citation: Journal of Inflammation 2019 16:24

    Content type: Research

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  42. Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus patients. Mesangial cells (MCs) comprise a third of the glomerular cells and are key contributors to fibrotic changes withi...

    Authors: Rachael D. Wright, Paraskevi Dimou, Sarah J. Northey and Michael W. Beresford

    Citation: Journal of Inflammation 2019 16:22

    Content type: Research

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  43. Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their f...

    Authors: Li Wang, Linjie Feng and Jingyu Zhang

    Citation: Journal of Inflammation 2019 16:21

    Content type: Commentary

    Published on:

    The original article was published in Journal of Inflammation 2019 16:13

  44. There is growing recognition of the association of CP/CPPS accompany with ED. However, the specific mechanism of action remains unclear. The aim of this study was to investigate structural and functional abnor...

    Authors: Tianrun Huang, Guangchun Wang, Yangyang Hu, Heng Shi, Keyi Wang, Lei Yin and Bo Peng

    Citation: Journal of Inflammation 2019 16:20

    Content type: Research

    Published on:

  45. Emerging evidence has demonstrated that inflammation is involved in the occurrence and development of diabetic neuropathic pain (DNP). The anti-inflammatory property of interleukin (IL)-35 makes it a promising...

    Authors: Yinghai Jiang, Jing Wang, Haiqin Li and Lingjie Xia

    Citation: Journal of Inflammation 2019 16:19

    Content type: Research

    Published on:

  46. Caused by Mycobacterium tuberculosis, tuberculosis (TB) is an extremely contagious disease predominantly affecting the lungs. TB is found worldwide and has a major impact on public health safety primarily due to ...

    Authors: Paulo R. Z. Antas, Carlos G. G. Ponte, Matheus R. Almeida, Lawrence H. P. Albuquerque, Periela S. Sousa-Vasconcelos, Thaíze Pedro, Natália L. S. Gomes, Otacílio C. Moreira, Fernanda C. Silva, Luíz R. R. Castello-Branco and Rosa T. Pinho

    Citation: Journal of Inflammation 2019 16:18

    Content type: Research

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  47. Obesity-induced skeletal muscle inflammation is a major contributor of skeletal muscle loss/atrophy and is implicated in metabolic complications such as insulin resistance. Fibroblast growth factor 21 (FGF21) ...

    Authors: Chu-Sook Kim, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Jeong Woo Park, Hun Taeg Chung, Eun Roh, Min-Seon Kim, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2019 16:17

    Content type: Research

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  48. Dysregulated inflammatory response is common cause of organ damage in critical care patients. Preconditioning/tolerance is a strategy to prevent exacerbated inflammation. The aim of this study is to analyze hy...

    Authors: Rosangela Nascimento Pimentel, Ricardo Costa Petroni, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Mariana Macedo Andrade, Suely Kumini Ariga and Francisco Garcia Soriano

    Citation: Journal of Inflammation 2019 16:16

    Content type: Research

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  49. The discovery of the NET network (neutrophil extracellular trap) has revolutionized the perception of defense mechanisms used by neutrophils in infections and non-infectious states, as this mechanism proves th...

    Authors: Paulina Niedźwiedzka-Rystwej, Weronika Repka, Beata Tokarz-Deptuła and Wiesław Deptuła

    Citation: Journal of Inflammation 2019 16:15

    Content type: Review

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  50. Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t...

    Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, Jürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf

    Citation: Journal of Inflammation 2019 16:14

    Content type: Research

    Published on:

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