Articles

Therapeutic potential of a novel semi-synthetic-sulfated-polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages

Chronic periodontitis is associated with an increased risk for systemic conditions such as cardiovascular disease, diabetes, and osteoporosis. During chronic periodontitis, endotoxin (lipopolysaccharide, LPS) ...

Authors: Ying Gu, Veena Raja, Hsi-Ming Lee, Houlin Hong, Glenn Prestwich and Maria E. Ryan

USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway

Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathogenesis and treatment of acute kidney injury (AKI) is of great signific...

Authors: Fei Gao, Mingjiang Qian, Guoyue Liu, Wanping Ao, Dahua Dai and Cunzhi Yin

Increased levels of S100A8/A9, IL-1ß and IL-18 as a novel biomarker for recurrent tonsillitis

Acute tonsillitis represents one of the most frequent reasons patients seek primary medical care and otorhinolaryngology consultation. Therefore, recurrent episodes of acute tonsillitis (RAT), also called chro...

Authors: Christoph Spiekermann, Alicia Seethaler, Annika McNally, Markus Stenner, Claudia Rudack, Johannes Roth and Thomas Vogl

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD). However, only a limited number of ICD-in...

Authors: Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu and Qing An

The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabil...

Authors: Hsin-Hui Hsieh, Yen-An Chen, Yao-Jen Chang, Hsin-Hui Wang, Ya-Han Yu, Sheng-Wei Lin, Yin-Jung Huang, Steven Lin and Ching-Jin Chang

Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm

Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted inflammatory factors have an association with the outcome of inflammation. Luteolin, a flavonoid a...

Authors: Shuxia Wang, Shuhang Xu, Jing Zhou, Li Zhang, Xiaodong Mao, Xiaoming Yao and Chao Liu

Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway

Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj...

Authors: Xiao-Xia Gu, Xiao-Xia Xu, Hui-Hua Liao, Ruo-Na Wu, Wei-Ming Huang, Li-Xia Cheng, Yi-Wen Lu and Jian Mo

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke.

Authors: Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant and Sandra J. Hodge

VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation

Anti-vascular endothelial growth factor (VEGF) has been used as a therapeutic drug for the treatment of some human diseases. However, no systematic evidence is performed for assessing the role of VEGF in perio...

Authors: Bo Ren, Que Feng, Shan He, Yanfeng Li, Jiadong Fan, Guangquan Chai, Le Liu, Haiyun Liu, Chunhao Yang, Yingdi Wang, Huihui Liu, Huanyue Liu and Yafan Song

Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway

Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injur...

Authors: Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas and Yohannes T. Ghebre

The impact of E-cigarette vaping and vapour constituents on bone health

In contrast to cigarettes, electronic cigarette use (E-cigarettes) has grown substantially over the last decade. This is due to their promotion as both a safer alternative to cigarettes and as an aide to stop ...

Authors: Thomas Nicholson, Aaron Scott, Matthew Newton Ede and Simon W. Jones

Correction to: Research Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

Authors: John A. Marwick, Christopher S. Stevenson, Kian Fan Chung, Ian M. Adcock and Paul A. Kirkham

Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma.

Authors: Asheed Almohammai, Reza Rahbarghazi, Rana Keyhanmanesh, Jafar Rezaie and Mahdi Ahmadi

Interleukin 10 and interleukin 10 receptor in paediatric inflammatory bowel disease: from bench to bedside lesson

The differences between adults and children in inflammatory bowel disease (IBD) phenotype, severity, complications, co-morbidities, and response to the therapy resulted in the extraction of paediatric IBD. It ...

Authors: Paulina Krawiec, Agnieszka Pawłowska-Kamieniak and Elżbieta Pac-Kożuchowska

LncRNA TUG1 regulates the development of ischemia-reperfusion mediated acute kidney injury through miR-494-3p/E-cadherin axis

Acute kidney injury (AKI) results from renal dysfunction caused by various causes, resulting in high mortality. The underlying mechanisms of ischemia-reperfusion (I/R) induced AKI is very complicated and neede...

Authors: Li Chen, Jun-Ying Xu and Hong-Bao Tan

Pellino1 promoted inflammation in lung injury model of sepsis by TRAF6/ NF-κB signal pathway

This study was designed to investigate the role of Pellino1 in lung injury model of sepsis and its anti-inflammation mechanism.

Authors: Xiaqing Liu, Zhengfang Lin and Yufeng Xu

Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells

Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA...

Authors: Aysan Eslami Abriz, Reza Rahbarghazi, Alireza Nourazarian, Çıgır Biray Avci, Soltan Ali Mahboob, Maryam Rahnema, Atefeh Araghi and Morteza Heidarzadeh

Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression

TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transd...

Authors: Shudong Liu, Jie Wang, Wenyan Li, Hui Shi, Changlong Zhou, Ge Tang, Jiangwei Zhang and Zhao Yang

MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway

Sepsis is a complex syndrome characterized by a dysregulated inflammatory response to systemic infection and leads to shock, multiple organ failure and death especially if not recognized early and treated prom...

Authors: Wei Wang, Rong-Li Xu, Ping He and Rui Chen

Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway

Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical role in AKI and subsequent kidney repair through the regulation of vario...

Authors: Chong Huang, Yan Chen, Bin Lai, Yan-Xia Chen, Cheng-Yun Xu and Yuan-Fei Liu

Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over‐mechanical stretching stress

Intervertebral disk degeneration (IVDD) contributes to low back pain. Increased cell apoptosis and inflammation, decreased extracellular matrix are associated with IVDD. Nuclear factor-kappa B (NF-κB) signalin...

Authors: Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo and Zhongxu Cai

Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice

Obesity is an epidemic disease in the world, the treatment and prevention of obesity methods have gained great attention. Lactobacillus is the main member of probiotics, and the physiological activity of it is...

Authors: Ya Wu, Xueya Li, Fang Tan, Xianrong Zhou, Jianfei Mu and Xin Zhao

Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of a...

Authors: Afshin Rahbarghazi, Marefat Siahkouhian, Reza Rahbarghazi, Mahdi Ahmadi, Lotfali Bolboli, Rana Keyhanmanesh, Mahdi Mahdipour and Hadi Rajabi

Anti-inflammatory potential of Quercetin in COVID-19 treatment

SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible f...

Authors: Ali Saeedi-Boroujeni and Mohammad-Reza Mahmoudian-Sani

Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells

NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which ...

Authors: Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Takahiko Tsukuda, Masataka Katakami, Toshio Ariyasu, Shimpei Ushio and Kanso Iwaki

Dexamethasone can attenuate the pulmonary inflammatory response via regulation of the lncH19/miR-324-3p cascade

To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment.

Authors: Ye Chen, Chao Zhang, Chang-xue Xiao, Xiao-dong Li, Zhi-li Hu, Shou-di He, Xiao-jun Xiao and Feng Xu

Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity

Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved ef...

Authors: Fang Cui, Jing Guo, Hao-Fei Hu, Yi Zhang and Min Shi

PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population

Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic comp...

Authors: Karina Vargas-Sánchez, Laura Vargas, Yenny Urrutia, Iván Beltrán, Ana Beatriz Rossi, Hernán Yupanqui Lozano, Jorge Guarín and Monica Losada-Barragán

Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functi...

Authors: James G. Macfarlane, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi and A. John Simpson

Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and res...

Authors: Mozhgan Jahani, Sadat Dokaneheifard and Kamran Mansouri

Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART

HIV infection is characterized by CD4⁺ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatm...

Authors: Mariana del Rocio Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Sarah Ratkovich-González, Karina Sánchez-Reyes, Luz A. González-Hernández, Jaime F. Andrade-Villanueva and Monserrat Alvarez-Zavala

LncRNA THRIL is upregulated in sepsis and sponges miR-19a to upregulate TNF-α in human bronchial epithelial cells

Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) relat...

Authors: Tao Liu, Jingbin Liu, Chunhua Tian, Hongyuan Wang, Min Wen and Mingyu Yan

Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway

Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the thera...

Authors: Shi-Jian Yi, Yang Wu, Lan-Lan Li, Qian-Kun Liang and Yue Xiao

Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis

Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and includ...

Authors: Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch…

Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women

Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL defi...

Authors: Sofie Jacobson, Peter Larsson, Anna-Maja Åberg, Göran Johansson, Ola Winsö and Stefan Söderberg

Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion rep...

Authors: Ludmila Khailova, Justin Robison, James Jaggers, Richard Ing, Scott Lawson, Amy Treece, Danielle Soranno, Suzanne Osorio Lujan and Jesse A. Davidson

Emodin alleviates LPS-induced inflammatory response in lung injury rat by affecting the function of granulocytes

Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that l...

Authors: Hongxia Mei, Ying Tao, Tianhao Zhang and Feng Qi

N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis

NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactiv...

Authors: Fenglian He, Guanghui Zheng, Jingying Hou, Qiaohua Hu, Qin Ling, Gongfa Wu, Hui Zhao, Jin Yang, Yue Wang, Longyuan Jiang, Wanchun Tang and Zhengfei Yang

Offspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice

Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ...

Authors: Baoming Wang, Yik Lung Chan, Shengyu Zhou, Sonia Saad, Hui Chen and Brian G Oliver

Potential interaction between lysophosphatidic acid and tumor-associated macrophages in ovarian carcinoma

Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor microenvironment enables specific and efficient metastasis, weakens immunological monitoring, and mediates drug resistance. Tum...

Authors: Ying Feng, Meizhu Xiao, Zihan Zhang, Ran Cui, Xuan Jiang, Shuzhen Wang, Huimin Bai, Chongdong Liu and Zhenyu Zhang

NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway

Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activati...

Authors: Biao Tang, Dan Liu, Lingyu Chen and Yu Liu

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping

The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that ...

Authors: Gagandeep Kaur, Giuseppe Lungarella and Irfan Rahman

A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis

Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas...

Authors: Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong and Heeyeong Cho

Efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia, a multicenter, randomized, double-blind, placebo-controlled trial

To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia.

Authors: Rongmeng Jiang, Bing Han, Meihua Song, Bing Xue, Yongxiang Zhang, Yanyan Ding, Jin Chen, Jing Zhu, Jianhua Liu, Qingrong Nie, Xuefeng Han, Xiuhong Jin, Xiaoyin Shan, Weian Guo, Erming Zhang, Zuoqing Zhang…

Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine

Dexmedetomidine (Dex) is a highly selective agonist of the α2 adrenergic receptor and a common sedative; however, its anti-inflammatory effect has been studied. In this study, the inhibitory effect of Dex on i...

Authors: Gang Lv, Guanhua Zhu, Maohua Xu, Xingping Gao and Qingfeng Xiao

MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model

Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo...

Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Qijiang Xiong, Ling Yang, Zhongyan Huang and Zhao Yang

Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enha...

Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons and Sandra Hodge

Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies

Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these in...

Authors: Amandip Kaur and Paraskevi Goggolidou

Elevated soluble TNFα levels and upregulated TNFα mRNA expression in purified peripheral blood monocyte subsets associated with high-grade hepatocellular carcinoma

Chronic inflammation is involved in the initiation and progression of various cancers, including liver cancer. The current study focuses on the characterization of the peripheral immune response in hepatocellu...

Authors: C. Martín-Sierra, R. Martins, M. Coucelo, A. M. Abrantes, R. C. Oliveira, J. G. Tralhão, M. F. Botelho, E. Furtado, M. R. Domingues, A. Paiva and P. Laranjeira

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes

Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol...

Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan