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  1. Content type: Research

    The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r...

    Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan

    Citation: Journal of Inflammation 2018 15:25

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  2. Content type: Research

    Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ...

    Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura

    Citation: Journal of Inflammation 2018 15:26

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  3. Content type: Research

    Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo...

    Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda

    Citation: Journal of Inflammation 2018 15:24

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  4. Content type: Research

    Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer’s d...

    Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2018 15:23

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  6. Content type: Research

    High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate...

    Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen

    Citation: Journal of Inflammation 2018 15:21

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  7. Content type: Research

    Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul...

    Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz

    Citation: Journal of Inflammation 2018 15:20

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  8. Content type: Research

    Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin...

    Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin

    Citation: Journal of Inflammation 2018 15:19

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  10. Content type: Research

    Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab...

    Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker

    Citation: Journal of Inflammation 2018 15:18

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  11. Content type: Research

    The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as...

    Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang

    Citation: Journal of Inflammation 2018 15:16

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  12. Content type: Research

    T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies ind...

    Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang and Xu D. Xiang

    Citation: Journal of Inflammation 2018 15:15

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  13. Content type: Research

    Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperi...

    Authors: Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao and Mingzhi Gong

    Citation: Journal of Inflammation 2018 15:14

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  14. Content type: Research

    The CARD family plays an important role in innate immune response by the activation of NF-κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some me...

    Authors: Jesús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez and Montserrat A. Lara-Velazquez

    Citation: Journal of Inflammation 2018 15:13

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  15. Content type: Research

    Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2...

    Authors: Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede and Tobias Hilbert

    Citation: Journal of Inflammation 2018 15:12

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  16. Content type: Research

    Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant...

    Authors: Diego A. Vicente, Matthew J. Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A. Elster and Thomas A. Davis

    Citation: Journal of Inflammation 2018 15:11

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  17. Content type: Research

    Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors imp...

    Authors: Christian Patry, Daniela Stamm, Christian Betzen, Burkhard Tönshoff, Benito A. Yard, Grietje Ch. Beck and Neysan Rafat

    Citation: Journal of Inflammation 2018 15:10

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  19. Content type: Research

    Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. T...

    Authors: K. L. C. da Silva, A. P. Camacho, F. C. Mittestainer, B. M. Carvalho, A. Santos, D. Guadagnini, A. G. Oliveira and M. J. A. Saad

    Citation: Journal of Inflammation 2018 15:8

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  20. Content type: Research

    Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiolog...

    Authors: Chunyan Lou and Yanyang Li

    Citation: Journal of Inflammation 2018 15:7

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  21. Content type: Correction

    Upon publication of the original article [1] it was highlighted by the authors that the first affiliation of author Haiyan Yin was incorrectly cited in duplicate as “Department of Neurology, Affiliated Hospita...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan

    Citation: Journal of Inflammation 2018 15:6

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    The original article was published in Journal of Inflammation 2017 14:17

  22. Content type: Research

    Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im...

    Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock

    Citation: Journal of Inflammation 2018 15:5

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  23. Content type: Research

    Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ...

    Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang

    Citation: Journal of Inflammation 2018 15:4

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  24. Content type: Research

    Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve...

    Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin

    Citation: Journal of Inflammation 2018 15:3

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  25. Content type: Research

    In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel...

    Authors: T. Smith, L. Engelbrecht and C. Smith

    Citation: Journal of Inflammation 2018 15:2

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  26. Content type: Research

    Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis...

    Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye

    Citation: Journal of Inflammation 2018 15:1

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  28. Content type: Research

    An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust eff...

    Authors: David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek and Sharath Hegde

    Citation: Journal of Inflammation 2017 14:28

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  29. Content type: Research

    Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 tr...

    Authors: Nina Falcon Bærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen and Ole Hyldegaard

    Citation: Journal of Inflammation 2017 14:27

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  30. Content type: Review

    Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included...

    Authors: Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong and Louis Tong

    Citation: Journal of Inflammation 2017 14:26

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  31. Content type: Research

    Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) h...

    Authors: Lei Yang, Lei Shen, Yue Li, Yanxia Li, Shijie Yu and Shanshan Wang

    Citation: Journal of Inflammation 2017 14:25

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  32. Content type: Research

    Inflammatory cytokines have been demonstrated to be involved in developing insulin resistance and type-2 diabetes (T2D). Natural antibodies in the circulation have protective effects on common diseases in huma...

    Authors: Weiyi Cai, Cailing Qiu, Hongyu Zhang, Xiangyun Chen, Xuan Zhang, Qingyong Meng and Jun Wei

    Citation: Journal of Inflammation 2017 14:24

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  33. Content type: Research

    Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a ...

    Authors: Matthew J. Bradley, Diego A. Vicente, Benjamin A. Bograd, Erin M. Sanders, Crystal L. Leonhardt, Eric A. Elster and Thomas A. Davis

    Citation: Journal of Inflammation 2017 14:23

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  34. Content type: Research

    This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vi...

    Authors: Maria Luisa Molina, Julia Guerrero, John A. Cidlowski, Héctor Gatica and Annelise Goecke

    Citation: Journal of Inflammation 2017 14:22

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  35. Content type: Research

    The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced p...

    Authors: Tetsuya Yokoyama, Toyoshi Yanagihara, Kunihiro Suzuki, Naoki Hamada, Kazuya Tsubouchi, Saiko Ogata-Suetsugu, Hironori Mikumo, Chika Ikeda-Harada, Takashige Maeyama, Kazuyoshi Kuwano and Yoichi Nakanishi

    Citation: Journal of Inflammation 2017 14:20

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  36. Content type: Short Report

    In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, us...

    Authors: Torbjörn Karlsson

    Citation: Journal of Inflammation 2017 14:21

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  37. Content type: Research

    Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be invol...

    Authors: Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö and Stefan Söderberg

    Citation: Journal of Inflammation 2017 14:19

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  39. Content type: Research

    Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators ...

    Authors: Haiyan Yin, Shuwen Song and Xudong Pan

    Citation: Journal of Inflammation 2017 14:17

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    The Correction to this article has been published in Journal of Inflammation 2018 15:6

  40. Content type: Review

    Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transd...

    Authors: Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang and Ke Jiang

    Citation: Journal of Inflammation 2017 14:16

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  42. Content type: Research

    Indeed, intracerebral hemorrhage (ICH) account for only 15% of all strokes but it is one of the most devastating subtype of stroke associated with behavioral, cognitive and neurological deficits. The primary c...

    Authors: Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra and Anurag Kuhad

    Citation: Journal of Inflammation 2017 14:14

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  43. Content type: Research

    Traumatic brain injury (TBI) is a public health issue. As the major complaint in 51% of TBI patients, chronic pain is an important aspect in TBI treatment. Tetramethylpyrazine (TMP) is an important compound in Li...

    Authors: Zhijing Wang, Qi Wang, Cuijie Wang, Xiuzhen Xu and Hongmei Yu

    Citation: Journal of Inflammation 2017 14:13

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  44. Content type: Review

    The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INte...

    Authors: Yang Li, Heather L. Wilson and Endre Kiss-Toth

    Citation: Journal of Inflammation 2017 14:11

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  45. Content type: Research

    The red cell distribution width (RDW) is a widely available, inexpensive, and highly reproducible test that reflects the range of the red cell sizes. Any process that releases reticulocytes in the circulation ...

    Authors: Tom Schepens, Jozef J. De Dooy, Walter Verbrugghe and Philippe G. Jorens

    Citation: Journal of Inflammation 2017 14:12

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  46. Content type: Short report

    Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular e...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Journal of Inflammation 2017 14:10

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  47. Content type: Short Report

    Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We pre...

    Authors: Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha and Rina Yu

    Citation: Journal of Inflammation 2017 14:9

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  48. Content type: Research

    Adipocyte fatty acid-binding protein, also known as aP2 or fatty acid-binding protein 4 (FABP4), plays an important role in inflammatory and metabolic responses in adipocytes and macrophages. Recent work has d...

    Authors: Qian Wang, Guanglin Shi, Ying Teng, Xia Li, Jin Xie, Qin Shen, Caixin Zhang, Songshi Ni and Zhiyuan Tang

    Citation: Journal of Inflammation 2017 14:8

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  49. Content type: Research

    Ulinastatin or urinary trypsin inhibitor (UTI) has been shown to ameliorate the inflammatory response induced by experimental severe acute pancreatitis (SAP) and hence reduce the mortality, however the mechani...

    Authors: Yu Pan, Haizong Fang, Fengchun Lu, Minggui Pan, Fei Chen, Ping Xiong, Yi Yao and Heguang Huang

    Citation: Journal of Inflammation 2017 14:7

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  50. Content type: Research

    The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression of a...

    Authors: Li Cai, Chao Lei, Rong Li, Wei-na Chen, Cheng-mu Hu, Xiao-yu Chen and Chun-mei Li

    Citation: Journal of Inflammation 2017 14:6

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