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  1. Content type: Research

    Cytosine-phosphate-guanine (CpG) oligodeoxyribonucleotides (ODNs) are synthetic DNA fragments containing unmethylated cytosine-guanine motifs with potential immune modulatory effects and have recently been sug...

    Authors: Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang, Jihong Zhang and Hui Bin Sun

    Citation: Journal of Inflammation 2016 13:16

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  2. Content type: Research

    In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action o...

    Authors: Torsten Lowin, Georg Pongratz and Rainer H. Straub

    Citation: Journal of Inflammation 2016 13:15

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  3. Content type: Research

    Intimate links connect tissue factor (TF), the principal initiator of the clotting cascade, to inflammation, a cross-talk amplified by locally generated Angiotensin (AT) II, the effector arm of the Renin Angio...

    Authors: Cristina Balia, Valentina Scalise, Silvana Cianchetti, Francesca Faita, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Alessandro Celi and Roberto Pedrinelli

    Citation: Journal of Inflammation 2016 13:14

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  4. Content type: Research

    Hyperglycemia is a frequent and important metabolic derangement that accompanies severe sepsis and septic shock. Matrix-Metalloproteinase 9 (MMP-9) has been shown to be elevated in acute stress hyperglycemia, ...

    Authors: Gul R. Sachwani, Anja K. Jaehne, Namita Jayaprakash, Mark Kuzich, Violet Onkoba, Dione Blyden and Emanuel P. Rivers

    Citation: Journal of Inflammation 2016 13:13

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  5. Content type: Research

    Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal pr...

    Authors: Akash Fichadiya, Karri L Bertram, Guomin Ren, Robin M Yates and Roman J Krawetz

    Citation: Journal of Inflammation 2016 13:12

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  6. Content type: Review

    Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease. Patients with ECRS present with thick mucus production, long-term nasal congestion, loss of sense of smell, and in...

    Authors: Said Ahmad Shah, Hajime Ishinaga and Kazuhiko Takeuchi

    Citation: Journal of Inflammation 2016 13:11

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  7. Content type: Research

    Pretreatment with low doses of LPS (lipopolysaccharide, bacterial endotoxin) reduces the pro-inflammatory response to a subsequent higher LPS dose, a phenomenon known as endotoxin tolerance. Moreover, hydrogen...

    Authors: Ester C. S. Rios, Francisco G. Soriano, Gabor Olah, Domokos Gerö, Bartosz Szczesny and Csaba Szabo

    Citation: Journal of Inflammation 2016 13:10

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  8. Content type: Research

    It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in juvenile rats induces a chronic reduction in the apparent diffusion coeffi...

    Authors: Raman Saggu

    Citation: Journal of Inflammation 2016 13:9

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    The Erratum to this article has been published in Journal of Inflammation 2016 13:17

  9. Content type: Research

    The amount of urinary glycoprotein lipocalin 2 (LCN2) has been known to increase after kidney injury because of failed reabsorption by the proximal tubules or direct secretion from injured tissues. However, th...

    Authors: Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura and Taka-aki Koshimizu

    Citation: Journal of Inflammation 2016 13:7

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  10. Content type: Research

    Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin an...

    Authors: Gregory B. Pott, Mark Tsurudome, Nadia Bamfo and Marc L. Goalstone

    Citation: Journal of Inflammation 2016 13:6

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  11. Content type: Short report

    The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction...

    Authors: Nancy A. Erickson, Lars Mundhenk, Samoa Giovannini, Rainer Glauben, Markus M. Heimesaat and Achim D. Gruber

    Citation: Journal of Inflammation 2016 13:5

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  12. Content type: Short report

    Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains larg...

    Authors: Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li and Hua Wu

    Citation: Journal of Inflammation 2016 13:4

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  13. Content type: Research

    In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promisin...

    Authors: Arash Moghaddam, Lisa Breier, Patrick Haubruck, Daniel Bender, Bahram Biglari, Andreas Wentzensen and Gerald Zimmermann

    Citation: Journal of Inflammation 2016 13:3

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  14. Content type: Review

    CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migratio...

    Authors: Jing Lu, Mita Chatterjee, Hannes Schmid, Sandra Beck and Meinrad Gawaz

    Citation: Journal of Inflammation 2016 13:1

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  15. Content type: Research

    Different subsets of tumor infiltrating T lymphocytes are believed to play essential role in the immune response to cancer cells. The data of these cells in NSCLC are relatively rare and controversial therefor...

    Authors: Jurgita Jackute, Marius Zemaitis, Darius Pranys, Brigita Sitkauskiene, Skaidrius Miliauskas, Vytis Bajoriunas, Simona Lavinskiene and Raimundas Sakalauskas

    Citation: Journal of Inflammation 2015 12:63

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  16. Content type: Research

    Hyperinflammation is a hallmark feature of cystic fibrosis (CF) airways. However, inflammation has also been documented systemically and, more recently, in extrapulmonary CF-affected tissues such as the pancre...

    Authors: Karoline St-Martin Crites, Geneviève Morin, Valérie Orlando, Natacha Patey, Catherine Cantin, Judith Martel, Emmanuelle Brochiero and Geneviève Mailhot

    Citation: Journal of Inflammation 2015 12:62

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  17. Content type: Research

    Inflammation is known to worsen cerebral damage at the acute phase of stroke. In this setting, cell adhesion molecules (CAMs) play a crucial role mediating migration of immune cells into the infarcted area. Ho...

    Authors: Sébastien Richard, Linnéa Lagerstedt, Pierre R. Burkhard, Marc Debouverie, Natacha Turck and Jean-Charles Sanchez

    Citation: Journal of Inflammation 2015 12:61

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  18. Content type: Research

    Tuberculosis (TB) is the second greatest killer worldwide that is caused by a single infectious agent. For its control, studies of TB vaccines are needed. Since Bacillus Calmette-Guerin (BCG) is the only vacci...

    Authors: Jessica Lima, Mariana Siqueira, Thaíze Pedro, Carlos Ponte, Leandro Peres, Suelen Marinho, Luíz R. Castello-Branco and Paulo R. Z. Antas

    Citation: Journal of Inflammation 2015 12:60

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  19. Content type: Research

    It is known that both human conjunctival fibroblasts (HCF) and corneal epithelial (HCE) cells contribute to the inflammatory process in the ocular surface by releasing inflammatory cytokines. In addition, nitr...

    Authors: Nir Erdinest, Noam Shohat, Eli Moallem, Claudia Yahalom, Hadas Mechoulam, Irene Anteby, Haim Ovadia and Abraham Solomon

    Citation: Journal of Inflammation 2015 12:59

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  20. Content type: Research

    Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free f...

    Authors: Simon Schneider, Petra Hoppmann, Werner Koch, Stephan Kemmner, Christoph Schmaderer, Lutz Renders, Adnan Kastrati, Karl-Ludwig Laugwitz, Uwe Heemann and Marcus Baumann

    Citation: Journal of Inflammation 2015 12:57

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  21. Content type: Research

    Physical exercise induces neuroprotection through anti-inflammatory effects and total sleep deprivation is reported an inflammatory process. We examined whether 7 weeks of exercise training attenuates markers ...

    Authors: M. Chennaoui, D. Gomez-Merino, C. Drogou, H. Geoffroy, G. Dispersyn, C. Langrume, S. Ciret, T. Gallopin and F. Sauvet

    Citation: Journal of Inflammation 2015 12:56

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  22. Content type: Research

    Unresolved and prolonged inflammation is a pathological basis of many disorders such as cancer and multiple organ failure in shock. Interleukin-1 receptor (IL-1R) superfamily consists of IL-1R1 and pathogen pa...

    Authors: Prachi Vilekar, Geeta Rao, Shanjana Awasthi and Vibhudutta Awasthi

    Citation: Journal of Inflammation 2015 12:55

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  23. Content type: Research

    The activity of one of the major catechins in Green Tea, the polyphenol (−)-epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits. Recent studies suggest that EGCG can modulate...

    Authors: So-Youn Min, Mei Yan, Sang Bum Kim, Sneha Ravikumar, Seong-Ryuel Kwon, Kamala Vanarsa, Ho-Youn Kim, Laurie S. Davis and Chandra Mohan

    Citation: Journal of Inflammation 2015 12:53

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  24. Content type: Research

    Focal cerebral ischemia induces an inflammatory response that when exacerbated contributes to deleterious outcomes. The molecular basis regarding the regulation of the innate immune response after focal cerebr...

    Authors: Frank J. Brand III, Juan Carlos de Rivero Vaccari, Nancy H. Mejias, Ofelia F. Alonso and Juan Pablo de Rivero Vaccari

    Citation: Journal of Inflammation 2015 12:52

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  25. Content type: Research

    Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, enha...

    Authors: Sarah Fox, Kieran A. Ryan, Alice H. Berger, Katie Petro, Soumita Das, Sheila E. Crowe and Peter B. Ernst

    Citation: Journal of Inflammation 2015 12:51

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  26. Content type: Short Report

    Emerging reports propose possible biomarkers that are related to inflammation, nutrition and lipid parameters for detection of the progression of atherosclerotic plaques, peripheral artery disease (PAD) and pa...

    Authors: Jiexia Chen, Lei Han, Xiaoyan Xu, Haiqin Tang, Hongyan Wang and Bin Wei

    Citation: Journal of Inflammation 2015 12:50

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  27. Content type: Short Report

    Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple s...

    Authors: Simon Gerhardt, Veronika König, Monika Doll, Tsige Hailemariam-Jahn, Igor Hrgovic, Nadja Zöller, Roland Kaufmann, Stefan Kippenberger and Markus Meissner

    Citation: Journal of Inflammation 2015 12:49

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  28. Content type: Review

    Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica incr...

    Authors: Mickael Essouma and Jean Jacques N. Noubiap

    Citation: Journal of Inflammation 2015 12:48

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  29. Content type: Research

    The aim of the present study is to investigate the effects of two structurally divergent coumarins, calipteryxin (1) and (3’S,4’S)-3’,4’-disenecioyloxy-3’,4’-dihydroseselin (2) from Seseli recinosum, in lipopolys...

    Authors: Salman Khan, Omer Shehzad, Mao-Sheng Cheng, Rui-Juan Li and Yeong Shik Kim

    Citation: Journal of Inflammation 2015 12:47

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  30. Content type: Research

    This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms.

    Authors: Dan Li, Xiao-Wei Zhang, Xing-Quan Jiang, Yong-Jie Yin, Zhe Fan, Cheng-Bo Sun, Xing-Hai Chen, Yan-Hui Li and Ke-Xiang Liu

    Citation: Journal of Inflammation 2015 12:46

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  31. Content type: Review

    Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials. Furthermore, they are equipped with Ca2+ signaling systems...

    Authors: Elisabeth Hansson and Eva Skiöldebrand

    Citation: Journal of Inflammation 2015 12:44

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  32. Content type: Research

    Status epilepticus (SE) can cause neuronal cell death and impaired behavioral function. Acute exposure to potent acetylcholinesterase inhibitors such as soman (GD) can cause prolonged SE activity, micro-hemorr...

    Authors: Erik A. Johnson, Michelle A. Guignet, Thuy L. Dao, Tracey A. Hamilton and Robert K. Kan

    Citation: Journal of Inflammation 2015 12:43

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  33. Content type: Research

    The tristetraprolin (TTP) family of mRNA-binding proteins contains three major members, Ttp, Zfp36l1, and Zfp36l2. Ttp down-regulates the stability of AU-rich element–containing mRNAs and functions as an anti-...

    Authors: Kuan-Ting Wang, Hsin-Hui Wang, Yan-Yun Wu, Yu-Lun Su, Pei-Yu Chiang, Nien-Yi Lin, Shun-Chang Wang, Geen-Dong Chang and Ching-Jin Chang

    Citation: Journal of Inflammation 2015 12:42

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  34. Content type: Short Report

    Nur77, an orphan member of the nuclear receptor superfamily, has been implicated in the regulation of inflammation. However, the in vivo function of Nur77 remains largely unexplored. In the current study, we inv...

    Authors: Xiu-Ming Li, Xing-Xing Lu, Qian Xu, Jing-Ru Wang, Shen Zhang, Peng-Da Guo, Jian-Ming Li and Hua Wu

    Citation: Journal of Inflammation 2015 12:40

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  35. Content type: Short Report

    Immunomodulatory effects in humans of Δ9−Tetrahydrocannabinol (THC), the psychoactive component of marijuana are controversial. Tissue factor (TF), the activator of the extrinsic coagulation cascade, is increased...

    Authors: Julie C. Williams, Thomas W. Klein, Bruce A. Goldberger, John W. Sleasman, Nigel Mackman and Maureen M. Goodenow

    Citation: Journal of Inflammation 2015 12:39

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  36. Content type: Research

    Systemic Lupus Erythematosus (SLE) is an auto-immune disease whose complex pathogenesis remains unraveled. Here we aim to explore the inflammatory ability of SLE patients’ sera upon peripheral blood (PB) monoc...

    Authors: Tiago Carvalheiro, Diane Gomes, Ligia A. Pinto, Luis Inês, Ana Lopes, Ana Henriques, Susana Pedreiro, António Martinho, Hélder Trindade, Howard A. Young, José António Pereira da Silva and Artur Paiva

    Citation: Journal of Inflammation 2015 12:38

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  37. Content type: Research

    There is mounting evidence to support the role of inflammation in benign prostate hyperplasia (BPH), and a recent study reported expression of inflammasome derived cytokine IL-18 in prostate biopsy of BPH pati...

    Authors: Mahendra Kashyap, Subrata Pore, Zhou Wang, Jeffrey Gingrich, Naoki Yoshimura and Pradeep Tyagi

    Citation: Journal of Inflammation 2015 12:37

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  38. Content type: Research

    The nuclear receptors PPAR-γ and LXRs regulate macrophage lipid metabolism and macrophage mediated inflammation. We examined the influence of these molecules on macrophage alternative activation, with particul...

    Authors: Gaetano Zizzo and Philip L Cohen

    Citation: Journal of Inflammation 2015 12:36

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  39. Content type: Research

    Acute ulcerative colitis is an inflammation-driven condition of the bowel. It hampers the general homeostasis of gut, resulting in decreased mucus production and epithelial cell renewal. Adiponectin (APN), an ...

    Authors: Kamaljeet Kaur, Arpit Saxena, Bianca Larsen, Samantha Truman, Nathan Biyani, Emma Fletcher, Manjeshwar Shrinath Baliga, Venkatesh Ponemone, Shweta Hegde, Anindya Chanda and Raja Fayad

    Citation: Journal of Inflammation 2015 12:35

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  40. Content type: Research

    This study was designed to investigate the effect of glucose 6-phosphate dehydrogenase (G6PD) deficiency on pro-inflammatory cytokine secretion using a palmitate-induced inflammation HepG2 in vitro model. The ...

    Authors: Hung-Chi Yang, Mei-Ling Cheng, Yi-Syuan Hua, Yi-Hsuan Wu, Hsin-Ru Lin, Hui-Ya Liu, Hung-Yao Ho and Daniel Tsun-Yee Chiu

    Citation: Journal of Inflammation 2015 12:34

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  41. Content type: Research

    Studies suggest that inflammation is a key factor in the pathogenesis of diabetes mellitus. Pro-inflammatory cytokines, such as IL-6 and TNF-alpha, are produced by adipose tissue in large quantities, in obese ...

    Authors: Francisca Adilfa de Oliveira Garcia, Jéssica Farias Rebouças, Teresa Queiroz Balbino, Teresinha Gonçalves da Silva, Carlson Hélder Reis de Carvalho-Júnior, Gilberto Santos Cerqueira, Gerly Anne de Castro Brito and Glauce Socorro de Barros Viana

    Citation: Journal of Inflammation 2015 12:33

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  42. Content type: Research

    MMP-9 is crucial for a normal immune response, but excessive release of this enzyme leads to severe tissue damage. Listeria monocytogenes (LM) is an opportunistic food-borne pathogen causing listerosis, meningiti...

    Authors: Puthiyaveetil Kochumon Shihab, Areej Al-Roub, Moneera Al-Ghanim, Anfal Al-Mass, Kazem Behbehani and Rasheed Ahmad

    Citation: Journal of Inflammation 2015 12:32

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  43. Content type: Research

    Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that recruits monocyte/macrophage to the site of tissue injury and plays a critical role in microvascular complications of diabetes. However, the...

    Authors: Huibin Huang, Guangjun Jing, Joshua J Wang, Nader Sheibani and Sarah X Zhang

    Citation: Journal of Inflammation 2015 12:31

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