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Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway

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The original article was published in Journal of Inflammation 2019 16:13

Abstract

Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.

Main text

Qihong Que. and colleagues [1] found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.

We declare no competing interests.

Conclusions

Qihong Que. and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research.

Availability of data and materials

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Abbreviations

CREB:

cyclic adenosine monophosphate (cAMP) response element-binding

OA:

osteoarthritis

PKA:

protein kinase A

Reference

  1. 1.

    Que Q, Guo X, Zhan L, et al. The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis. J Inflamm (Lond). 2019;16:13.

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Acknowledgements

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Funding

No funding was obtained for this study.

Author information

LW was a major contributor in writing the manuscript. All authors read and approved the final manuscript.

Correspondence to Li Wang.

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Keywords

  • GLP-1R
  • Liraglutide
  • PKA/CREB pathway
  • Inflammation
  • Osteoarthritis