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Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway
Journal of Inflammation volume 16, Article number: 21 (2019)
The Original Article was published on 06 June 2019
Abstract
Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.
Main text
Qihong Que. and colleagues [1] found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.
We declare no competing interests.
Conclusions
Qihong Que. and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research.
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Abbreviations
- CREB:
-
cyclic adenosine monophosphate (cAMP) response element-binding
- OA:
-
osteoarthritis
- PKA:
-
protein kinase A
Reference
Que Q, Guo X, Zhan L, et al. The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis. J Inflamm (Lond). 2019;16:13.
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LW was a major contributor in writing the manuscript. All authors read and approved the final manuscript.
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Wang, L., Feng, L. & Zhang, J. Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway. J Inflamm 16, 21 (2019). https://doi.org/10.1186/s12950-019-0225-z
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DOI: https://doi.org/10.1186/s12950-019-0225-z