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Table 1 Cytokine and chemokine genes, and those of receptors (in italics), known to be differentially transcribed in human M1 and M2 macrophage in vitro polarisation (Adapted from [28] and [27]).

From: Innate immunity and monocyte-macrophage activation in atherosclerosis

M1 > M2

M2 > M1

CXCL11

Insulin-like growth factor 1

CCL19

CCL23

CXCL10

CCL18

Tumour necrosis factor ligand superfamily, member 2

CCL13

CCL15

Bone morphogenic protein 2

Interleukin 12B

Hepatocyte growth factor

Interleukin 15

Fibroblast growth factor 13

Tumour necrosis factor ligand superfamily, member 10

CXCL1

Interleukin 6

Transforming growth factor β receptor II

CCL20

CXCR4

Visfatin

Mannose receptor C type 1 (CD206)

Endothelial cell growth factor

 

CCL1

 

CCL17

 

CCL22

 

CCL13

 

Transforming growth factor β2

 

CCR7

 

Interleukin 2 receptor α chain

 

Interleukin 15 receptor α chain

 

Interleukin 7 receptor

 
  1. CCL2 was upregulated in M-CSF differentiated macrophages in one study [27], whilst relatively increased by GM-CSF in another [28].
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Journal of Inflammation

ISSN: 1476-9255

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