Significant higher Expression in CCR5 wild type samples | ||||
---|---|---|---|---|
Gene | Location | Function | Ref. | |
1. | LRG1 | 19p13.3 | Protein-protein interaction, signal transduction, and cell adhesion and development. Expression during granulocyte differentiation. | [35] |
2. | CXCR2 | 2q35 | Receptor for interleukin 8 and chemokine ligand 1. Mediates neutrophil migration to sites of inflammation. | [44] |
3. | HSP70-2 | 6p21.3 | Located in the MHC complex class III region, in a cluster with two closely related genes which encode similar proteins. | [45] |
4. | CCRL2 | 3p21 | Encodes a chemokine receptor like protein, most closely related to CCR1. | [46] |
5. | RSRC1 | 3q25.32 | Spliceosome assembly and participate in multiple steps of mRNA splicing. | [47] |
Significant higher Expression in CCR5-delta32 samples | ||||
1. | CD6 | 11q13 | Involved in T-cell activation. | [48] |
2. | CD7 | 17q25.2-q25.3 | Found on thymocytes and mature T cells. Mediates T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. | [49] |
3. | CD30L | 9q33 | Early CD30 signalling is critical for Treg-mediated acute GVHD protection after major MHC-mismatch HSCT. | [50] |
4. | SIAT1 | 3q27-q28 | Catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. | [51] |
5. | ATP6V1A | 3q13.31 | Necessary for protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. | [52] |
6. | WD repeat domain | 3p21.31 | Interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. | [53] |