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Table 1 Gene expression and gene function

From: The effect of the CCR5-delta32 deletion on global gene expression considering immune response and inflammation

Significant higher Expression in CCR5 wild type samples

 

Gene

Location

Function

Ref.

1.

LRG1

19p13.3

Protein-protein interaction, signal transduction, and cell adhesion and development. Expression during granulocyte differentiation.

[35]

2.

CXCR2

2q35

Receptor for interleukin 8 and chemokine ligand 1. Mediates neutrophil migration to sites of inflammation.

[44]

3.

HSP70-2

6p21.3

Located in the MHC complex class III region, in a cluster with two closely related genes which encode similar proteins.

[45]

4.

CCRL2

3p21

Encodes a chemokine receptor like protein, most closely related to CCR1.

[46]

5.

RSRC1

3q25.32

Spliceosome assembly and participate in multiple steps of mRNA splicing.

[47]

Significant higher Expression in CCR5-delta32 samples

1.

CD6

11q13

Involved in T-cell activation.

[48]

2.

CD7

17q25.2-q25.3

Found on thymocytes and mature T cells. Mediates T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

[49]

3.

CD30L

9q33

Early CD30 signalling is critical for Treg-mediated acute GVHD protection after major MHC-mismatch HSCT.

[50]

4.

SIAT1

3q27-q28

Catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates.

[51]

5.

ATP6V1A

3q13.31

Necessary for protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.

[52]

6.

WD repeat domain

3p21.31

Interacts with serine/threonine kinase 11, and is implicated in cell growth arrest.

[53]