Treatment for sleep apnea by continuous positive airway pressure improves levels of inflammatory markers - a meta-analysis

Table 4 Selected studies measuring serum IL-6 before and after CPAP

Study	Study design	Study population characteristics	OSA definition	Minimum CPAP usage	Outcome
Arias et al. 2008 [73]	Cross-over	25 men	AHI ≥ 10	≥ 3.5 h/day for 3 months	No significant change
Burioka et al. 2008 [79]	Case–control	9 total	AHI > 30	5 h/day (mean) for 3 months	Significantly decreased
Carniero et al. 2009 [63]	Case–control	7 severely obese men	AHI > 30	≥ 5 h/day for 3 months	No significant change
Ryan et al. 2006 [76]	Case–control	49 men	AHI > 5	Compliant for 6 weeks	No significant change
Steiropoulos et al. 2009 [77]	Case–control	32 total	AHI > 5	≥ 4 h/day for 6 months	No significant change
Vgontzas et al. 2008 [78]	Case–control	16 total	AHI > 5	≥ 4 h/day, ≥ 5d/week for 3 months	No significant change
Ye et al. 2010 [80]	Case–control	10 total	AHI ≥ 20	> 4 h/day for 6 months	Significantly decreased
Yokoe et al. 2003 [18]	Case–control	17 total	AHI ≥ 20	1 month	Significantly decreased

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