Affiliated with the British Inflammation Research Association (BIRAs).
Articles
Page 1 of 15
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Citation: Journal of Inflammation 2024 21:8
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Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores
Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to identify sepsis early and then quickly intervene t...
Citation: Journal of Inflammation 2024 21:7 -
Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabo...
Citation: Journal of Inflammation 2024 21:6 -
The preventive effects of Lactobacillus casei 03 on Escherichia coli-induced mastitis in vitro and in vivo
Lactobacillus casei possesses many kinds of bioactivities, such as anti-inflammation and anti-oxidant, and has been applied to treating multiple inflammatory diseases. However, its role in mastitis prevention has...
Citation: Journal of Inflammation 2024 21:5 -
Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation
Tissue-plasminogen activator (tPA) is a serine protease well known for its fibrinolytic function. Recent studies indicate that tPA could also modulate inflammation via plasmin generation and/or by receptor mediat...
Citation: Journal of Inflammation 2024 21:4 -
Role of meningeal immunity in brain function and protection against pathogens
The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the l...
Citation: Journal of Inflammation 2024 21:3 -
Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain
4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and exhibits neuroprotective and anti-inflammatory activity. Given the established function of the cholinergic system in pain and in...
Citation: Journal of Inflammation 2024 21:2 -
Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome
Mitochondrial diseases (MDs) are genetic disorders characterized by dysfunctions in mitochondria. Clinical data suggest that additional factors, beyond genetics, contribute to the onset and progression of this...
Citation: Journal of Inflammation 2024 21:1 -
SARS-CoV-2 spike protein accelerates systemic sclerosis by increasing inflammatory cytokines, Th17 cells, and fibrosis
Coronavirus disease 2019 (COVID-19) induces a dysfunctional immune response, inflammation, autoantibody production, and coagulopathy, which are symptoms that bear resemblance to those of autoimmune diseases, i...
Citation: Journal of Inflammation 2023 20:46 -
Retraction Note: Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12950-015-0074-3.
Citation: Journal of Inflammation 2023 20:45 -
Lonicera japonica Thunb extract ameliorates lipopolysaccharide-induced acute lung injury associated with luteolin-mediated suppression of NF-κB signaling pathway
Lonicera japonica Thunb (LJT) is a commonly used herbal soup to treat inflammation-related diseases. However, the effect of LJT on ALI is unknown. The present study was aimed at investigating the protective ef...
Citation: Journal of Inflammation 2023 20:44 -
Circadian dependency of microglial heme oxygenase-1 expression and inflammation determine neuronal injury in hemorrhagic stroke
The heme oxygenase-1 (HO-1) enzyme pathway is of crucial importance in the removal of toxic blood components and regulation of neuroinflammation following hemorrhagic stroke. Although a circadian pattern depen...
Citation: Journal of Inflammation 2023 20:43 -
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Citation: Journal of Inflammation 2023 20:42 -
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resu...
Citation: Journal of Inflammation 2023 20:41 -
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process in the propagation of viral infection. The main consequence of COVID-19 is the inductio...
Citation: Journal of Inflammation 2023 20:40 -
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects, but underlying mechanisms remain to be fully uncovered. Based on recent exploratory ev...
Citation: Journal of Inflammation 2023 20:39 -
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how H...
Citation: Journal of Inflammation 2023 20:38 -
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effect and underlying mechanism of butyrate on myasthenia gravis (MG) remain unclear. The c...
Citation: Journal of Inflammation 2023 20:37 -
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD). Considering the excessive end...
Citation: Journal of Inflammation 2023 20:36 -
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was down...
Citation: Journal of Inflammation 2023 20:35 -
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonary diseases, and we are now lack of effective therapeutic methods. Inflammatory response...
Citation: Journal of Inflammation 2023 20:34 -
Advances in the study of macrophage polarization in inflammatory immune skin diseases
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type and the anti-inflammatory M2-type, both of which perform almost enti...
Citation: Journal of Inflammation 2023 20:33 -
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long latency period presents opportunities for early detection, lifestyle modification and inter...
Citation: Journal of Inflammation 2023 20:32 -
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various sepsis-related immune cell defects. Alternative splicing (AS), as a sepsis-related immu...
Citation: Journal of Inflammation 2023 20:31 -
Inhibition of COX-2 signaling favors E. coli during urinary tract infection
To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhibition, have been used to reduce pain and as an alternative treatment for uncomplicated ...
Citation: Journal of Inflammation 2023 20:30 -
Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to ...
Citation: Journal of Inflammation 2023 20:29 -
Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic obstructive pulmonary disease (COPD). Sodium pyruvate (NaPyr) is a natural antioxidant...
Citation: Journal of Inflammation 2023 20:28 -
Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Citation: Journal of Inflammation 2023 20:27 -
Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite a growing public awareness of the harmful effects of air pollution on human health, th...
Citation: Journal of Inflammation 2023 20:26 -
Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review
Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable biomarkers accurate to gestational weeks for infectious PTB prediction clinically. Infect...
Citation: Journal of Inflammation 2023 20:25 -
Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Acute liver failure (ALF) is one of the most common life-threatening diseases in adults without previous liver disease. Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that is widely d...
Citation: Journal of Inflammation 2023 20:24 -
The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats
To compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brachytherapy and stereotactic radiotherapy (SBRT).
Citation: Journal of Inflammation 2023 20:23 -
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation
Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling is one subset. This inflammatory response is heterogeneous with respect to the inducti...
Citation: Journal of Inflammation 2023 20:22 -
Ischemic stroke-related gene expression profiles across species: a meta-analysis
Stroke patients are often left with permanent disabilities with no regenerative treatment options. Unbiased RNA sequencing studies decoding the transcriptional signature of stroked tissue hold promise to ident...
Citation: Journal of Inflammation 2023 20:21 -
Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induced acute liver injury (APAP-ALI) and there are limited treatments for this condition. AT...
Citation: Journal of Inflammation 2023 20:20 -
Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely affecting patients’ physical and mental health. Accumulating evidence indicated that the immu...
Citation: Journal of Inflammation 2023 20:19 -
Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis
To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysr...
Citation: Journal of Inflammation 2023 20:18 -
Neutrophil extracellular traps in acute coronary syndrome
Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and deat...
Citation: Journal of Inflammation 2023 20:17 -
PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therape...
Citation: Journal of Inflammation 2023 20:16 -
First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation
The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC),...
Citation: Journal of Inflammation 2023 20:15 -
Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, there is no adequate therapeutic strategy to reverse the progression of OA. Many natural pl...
Citation: Journal of Inflammation 2023 20:14 -
Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury
Acute lung injury (ALI) is a life-threatening condition that fundamentally results from inflammation and edema in the lung. There are no effective treatments available for clinical use. Previously, we found th...
Citation: Journal of Inflammation 2023 20:13 -
Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model
Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation invo...
Citation: Journal of Inflammation 2023 20:12 -
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and...
Citation: Journal of Inflammation 2023 20:11 -
Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS
Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening res...
Citation: Journal of Inflammation 2023 20:10 -
Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) ...
Citation: Journal of Inflammation 2023 20:9 -
Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ
Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear Factor-κappa B (NF-κB) is a critical transcription factors family of the inflammatory pa...
Citation: Journal of Inflammation 2023 20:8 -
Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related a...
Citation: Journal of Inflammation 2023 20:7 -
C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice
Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections....
Citation: Journal of Inflammation 2023 20:6 -
Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway
Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. T...
Citation: Journal of Inflammation 2023 20:5
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