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  1. Research

    Successful reduction of inflammatory responses and arachidonic acid–cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein

    Adipocyte fatty acid-binding protein, also known as aP2 or fatty acid-binding protein 4 (FABP4), plays an important role in inflammatory and metabolic responses in adipocytes and macrophages. Recent work has d...

    Qian Wang, Guanglin Shi, Ying Teng, Xia Li, Jin Xie, Qin Shen, Caixin Zhang, Songshi Ni and Zhiyuan Tang

    Journal of Inflammation 2017 14:8

    Published on: 20 March 2017

  2. Research

    Overexpression of aquaporin 4 in articular chondrocytes exacerbates the severity of adjuvant-induced arthritis in rats: an in vivo and in vitro study

    The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression of a...

    Li Cai, Chao Lei, Rong Li, Wei-na Chen, Cheng-mu Hu, Xiao-yu Chen and Chun-mei Li

    Journal of Inflammation 2017 14:6

    Published on: 1 March 2017

  3. Research

    Influence of vaginal lactoferrin administration on amniotic fluid cytokines and its role against inflammatory complications of pregnancy

    An altered amniotic cytokine profile has been reported in inflammatory pregnancy complications with a leading role for IL-6, a marker of the foetal systemic inflammatory response. Up to this date there is no e...

    Martina Maritati, Manola Comar, Nunzia Zanotta, Silva Seraceni, Alessandro Trentini, Fabrizio Corazza, Fortunato Vesce and Carlo Contini

    Journal of Inflammation 2017 14:5

    Published on: 15 February 2017

  4. Research

    Ezetimibe reduces cholesterol content and NF-kappaB activation in liver but not in intestinal tissue in guinea pigs

    Statins (HMG CoA reductase inhibitors), in addition to reducing circulating cholesterol and incidence of coronary heart disease, also have pleiotropic, anti-inflammatory effects. Patients with chronic liver di...

    Peter Fraunberger, Elisabeth Gröne, Hermann-Josef Gröne, Heinz Drexel and Autar K. Walli

    Journal of Inflammation 2017 14:3

    Published on: 2 February 2017

  5. Research

    Effects of corticosteroid plus long-acting beta2-agonist on the expression of PD-L1 in double-stranded RNA-induced lung inflammation in mice

    Airway viral infections cause the exacerbations of asthma and chronic obstructive pulmonary disease. PD-L1, also known as B7-H1, is an immune-checkpoint molecule that plays a role in an escape mechanism of vir...

    Saaka Hamano, Koichiro Matsumoto, Ken Tonai, Satoru Fukuyama, Keiko Kan-o, Nanae Seki, Hiromasa Inoue and Yoichi Nakanishi

    Journal of Inflammation 2017 14:2

    Published on: 17 January 2017

  6. Research

    Cardiovascular diseases-related GNB3 C825T polymorphism has a significant sex-specific effect on serum soluble E-selectin levels

    The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular e...

    Kokoè Mélinda Gbadoe, Nazha Berdouzi, Alex-Ander Aldasoro Aguiñano, Ndeye Coumba Ndiaye and Sophie Visvikis-Siest

    Journal of Inflammation 2016 13:39

    Published on: 9 December 2016

  7. Research

    Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes: significance in metabolic inflammation

    The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2 diabetes (T2D). While TLR2/4 expression changes asso...

    Rasheed Ahmad, Shihab Kochumon, Reeby Thomas, Valerie Atizado and Sardar Sindhu

    Journal of Inflammation 2016 13:38

    Published on: 8 December 2016

  8. Research

    Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls Staphylococcus aureus infection by boosting murine macrophage function and regulates inflammation

    Macrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphyloco...

    Somrita Dey and Biswadev Bishayi

    Journal of Inflammation 2016 13:36

    Published on: 28 November 2016

  9. Review

    Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review

    Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor invol...

    Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Federico Pierella, Flavio Del Bianco, Vincenzo Gentile, Ida Silvestri and Susanna Cattarino

    Journal of Inflammation 2016 13:35

    Published on: 25 November 2016

  10. Research

    Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide

    Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious and non-infectious neuropathologies, and its amelioration usually improves the patient outcome. Peripheral inflammation...

    G. Meneses, M. Bautista, A. Florentino, G. Díaz, G. Acero, H. Besedovsky, D. Meneses, A. Fleury, A. Del Rey, G. Gevorkian, G. Fragoso and E. Sciutto

    Journal of Inflammation 2016 13:33

    Published on: 29 October 2016

  11. Research

    Chondroprotective effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages

    Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also ...

    Christoph Bauer, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Daniela Kern, Stephan S. Späth and Stefan Nehrer

    Journal of Inflammation 2016 13:31

    Published on: 13 September 2016

  12. Research

    Circulating adipokine levels and prognostic value in septic patients

    Adipokines have a wide range of effects and are linked to sepsis and septic shock. The aim of the present study was to describe the changes in adipokine levels in septic patients in relation to patients’ prese...

    Andreas Hillenbrand, Pengfei Xu, Shaoxia Zhou, Annette Blatz, Manfred Weiss, Sebastian Hafner, Doris Henne-Bruns and Uwe Knippschild

    Journal of Inflammation 2016 13:30

    Published on: 6 September 2016

  13. Research

    Acidification changes affect the inflammasome in human nucleus pulposus cells

    Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions,...

    Frank J. Brand, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio and Juan Pablo de Rivero Vaccari

    Journal of Inflammation 2016 13:29

    Published on: 24 August 2016

  14. Research

    Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control i...

    Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller and Markus Meissner

    Journal of Inflammation 2016 13:27

    Published on: 20 August 2016

  15. Research

    Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

    The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasa...

    Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T. Hansel, Kian Fan Chung, Peter J. Barnes, Antonio Pastore, Stefano Pelucchi, Ian M. Adcock and Gaetano Caramori

    Journal of Inflammation 2016 13:26

    Published on: 4 August 2016

  16. Research

    Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice

    Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad...

    Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tschöpe and Sophie Van Linthout

    Journal of Inflammation 2016 13:25

    Published on: 2 August 2016

  17. Research

    A comparative study of blood endotoxin detection in haemodialysis patients

    Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endot...

    Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen and Ken Farrington

    Journal of Inflammation 2016 13:24

    Published on: 30 July 2016

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Affiliated with the British Inflammation Research Association (BIRAs).

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