Fig. 3
From: Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
PM2.5 aggravated cigarette smoke extract-induced inflammation in BEAS-2B cells. (A) PM2.5 and cigarette smoke extract decreased cell viability. (B) PM2.5 and cigarette smoke extract increased LDH release. (C) PM2.5 and cigarette smoke extract enhanced the release of IL-6 and IL-8 in the cell supernatant. (D) Relative mRNA expression level of IL-6 and IL-8. The data are represented as mean ± SD (n = 3). The significance is determined using one-way ANOVA, followed by post hoc Tukey’s test. * P < 0.05, ** P < 0.01, *** P < 0.001. CTL, control; CSE, cigarette smoke extract; PM, PM2.5; CSE + PM, cigarette smoke extract and PM2.5