Biomarker | Healthy Controls (n = 20) | PICU Day-1 Sepsis (n = 20) | PICU Day-2 Sepsis (n = 13) | P-value |
---|---|---|---|---|
G-CSF | 0 (0, 56.97) | 498.26 (219.98, 5422.09) | 426.49 (104.57, 681.23) | < 0.001 |
IL-1RA | 8.32 (3.71, 17.67) | 231.23 (126.02, 1075.80) | 75.22 (29.60, 224.32) | < 0.001 |
IL-6 | 0.67 (0.32, 1.68) | 288.22 (59.45, 3472.15) | 96.09 (24.35, 311.18) | < 0.001 |
IL-8 | 1.70 (1.10, 3.58) | 12.79 (6.30, 249.72) | 8.70 (5.98, 180.31) | < 0.001 |
IL-10 | 3.16 (0, 26.16) | 132.62 (30.15, 868.09) | 74.32 (23.20, 309.52) | < 0.001 |
IL-18 | 39.95 (28.15, 58.54) | 87.32 (59.95, 116.55) | 86.58 (76.50, 115.00) | < 0.001 |
MCP-1 | 224.6 (187.1, 281.8) | 1273.3 (724.8, 3637.4) | 842.7 (617.1, 4619.6) | < 0.001 |
M-CSF | 14.25 (0.51, 42.50) | 240.44 (141.53, 474.90) | 209.70 (119.20, 539.35) | < 0.001 |
MIP-1β | 25.98 (19.61, 35.02) | 56.85 (38.73, 131.75) | 71.72 (38.33, 112.04) | < 0.001 |
TNFα | 22.20 (10.11, 53.54) | 119.82 (41.25, 384.94) | 73.57 (36.37, 339.42) | < 0.001 |
RANTES | 10,590 (6150, 15,275) | 4811 (1939, 6417) | 4121 (1356, 4597) | < 0.001 |
MMP3 | 7414 (3751, 10,487) | 28,604 (21,388, 45,900) | 28,600 (19,827, 40,895) | < 0.001 |
MMP1 | 413.7 (367.6, 471.7) | 1374.5 (761.0, 3800.6) | 1099.4 (536.7, 1425.0) | < 0.001 |
MMP7 | 3892 (3279, 4360) | 7563 (4528, 11,636) | 7771 (6136, 13,026) | < 0.001 |
MMP10 | 444.2 (312.2, 616.1) | 2039.1 (971.6, 4170.0) | 2033.7 (1297.2, 4587.0) | < 0.001 |
Elastase 2 | 3.01 (1.60, 4.19) | 21.23 (13.72, 58.22) | 19.79 (8.71, 33.05) | < 0.001 |
HSP70 | 21,451 (19,626, 32,424) | 124,090 (64,321, 179,781) | 144,242 (69,428, 239,501) | < 0.001 |
MMP8 | 372.5 (217.7, 513.6) | 5089.1 (1129.6, 19915.9) | 6009.0 (1623.7, 15444.8) | < 0.001 |
Hyaluronan | 20.10 (14.85, 46.24) | 137.98 (85.20, 362.31) | 106.24 (55.31, 538.60) | < 0.001 |
NGAL | 60.86 (45.58, 95.74) | 223.05 (132.35, 1651.90) | 294.48 (134.41, 2063.79) | < 0.001 |
Resistin | 9.06 (6.41, 11.71) | 61.39 (19.75, 119.30) | 30.57 (17.70, 62.13) | < 0.001 |
MIG | 1295 (1013, 2772) | 3665 (1959, 13,735) | 2776 (1947, 5235) | 0.004 |
MMP9 | 16,018 (13,471, 18,928) | 10,235 (6335, 17,943) | 8586 (5882, 15,967) | 0.008 |
MMP2 | 115,962 (99,215, 133,619) | 98,954 (82,197, 106,700) | 90,882 (74,505, 109,475) | 0.009 |