Fig. 5

tPA modulated T cell activation during inflammation. A Dot plot analysis of CD3, CD4 and CD8 expression for quantification of T cell frequency (CD3⁺ CD4⁺ T or CD3⁺ CD8⁺ T) and CD44, CD69, CD25 for activated CD4⁺ or CD8⁺ T cells (CD3⁺ CD4⁺ CD44⁺/CD69⁺/CD25⁺ and CD3⁺ CD8⁺ CD44⁺/CD69⁺/CD25⁺). B Frequency of CD4⁺ T expressing CD44 (n = 5/group), CD69 (Sham WT; Sham tPA^−/− n = 5; LPS WT n = 4; LPS tPA^−/− n = 5) and CD25 (n = 5/group) activation markers. C Frequency of CD8⁺ T expressing CD44 (n = 5/group), CD69 (Sham WT n = 4; Sham tPA^−/−; LPS WT; LPS tPA^−/− n = 5) and CD25 (n = 5/group) activation markers. Data are shown as individual animals with mean ± SD, two-way ANOVA with Bonferroni’s post-hoc