Fig. 4

Analysis of microgliosis in the late stage mice in different brain regions revealed a region-dependent decrease in microgliosis in GFAP-IL6 mice due to NDUFS4 deficiency. a Representative images of IBA-1 staining. Scale bar 100 μm. b Quantification of IBA-1 fluorescence intensity in the VN, cerebellum, OB, cortex, and CA1, as well as the number of IBA-1⁺ cells in the cortex and CA1 of the different genotypes. ● Ndufs4 effect p ≤ 0.05, ★ GF-IL6 effect p ≤ 0.05, ♦ p ≤ 0.05 interaction between both factors