Gene | Control | H2O2 | Colchicine | H2O2 + Colchicine | P value |
---|---|---|---|---|---|
P21 | 1.00 ± 0.06 | 3.97 ± 0.47 | 1.93 ± 0.25 | 3.08 ± 0.34 | 0.0001 |
IL-1β | 1.10 ± 0.56 | 2.03 ± 0.10 | 0.40 ± 0.13 | 1.15 ± 0.31 | 0.0024 |
IL-6 | 1.00 ± 0.12 | 2.31 ± 0.28 | 1.74 ± 0.22 | 1.67 ± 0.10 | 0.0003 |
IL-8 | 1.01 ± 0.22 | 1.37 ± 0.22 | 1.46 ± 0.18 | 0.73 ± 0.02 | 0.0039 |
MCP-1 | 1.05 ± 0.36 | 1.87 ± 0.15 | 1.13 ± 0.19 | 0.38 ± 0.13 | 0.0003 |
ICAM-1 | 1.02 ± 0.26 | 2.26 ± 0.31 | 1.55 ± 0.06 | 1.54 ± 0.19 | 0.0012 |
VCAM-1 | 1.01 ± 0.18 | 1.30 ± 0.15 | 0.72 ± 0.08 | 1.42 ± 0.11 | 0.0009 |
E-Selectin | 1.03 ± 0.31 | 2.07 ± 0.09 | 0.56 ± 0.06 | 0.68 ± 0.27 | 0.0001 |
MMP-1 | 1.00 ± 0.04 | 2.07 ± 0.07 | 2.81 ± 0.06 | 3.75 ± 0.06 | 0.0001 |
MMP-2 | 1.00 ± 0.07 | 1.34 ± 0.07 | 0.95 ± 0.06 | 0.82 ± 0.05 | 0.0001 |
MMP-8 | 1.07 ± 0.44 | 1.66 ± 0.80 | 1.45 ± 0.30 | 1.41 ± 0.11 | 0.5538 |
MMP-11 | 1.00 ± 0.13 | 1.66 ± 0.19 | 1.05 ± 0.08 | 1.08 ± 0.18 | 0.0020 |
TIMP-1 | 1.03 ± 0.30 | 0.90 ± 0.10 | 1.79 ± 0.33 | 0.72 ± 0.14 | 0.0026 |
TIMP-2 | 1.00 ± 0.08 | 1.47 ± 0.24 | 1.69 ± 0.20 | 1.58 ± 0.10 | 0.0056 |