Fig. 6

sEH deficiency inhibited CSE-induced activation of the IRE1α/JNK/AP-1 pathway in BEAS-2B cells. (A-G) Western blotting evaluating the effect of si-sEH on the protein expression of GRP78, IRE1α, p-IRE1α, JNK, p-JNK, p38, p-p38, ERK1/2, p-ERK1/2 and AP-1 in BEAS-2B cells after stimulation with CSE. (H-J) Immunofluorescence was used to determine the p-IRE1α, p-JNK and AP-1expression in each group. Data represent the mean ± SD. ^*P < 0.05, ^***P < 0.001