Fig. 4

sEH deficiency suppressed CS-induced ER stress signaling in vivo. (A) Western blot showing changes in the protein expression of GRP78, IRE1α, p-IRE1α, PERK, p-PERK and ATF6 in the lung tissue of each group. (B-E) Quantifying GRP78, IRE1α, p-IRE1α, PERK, p-PERK and ATF6 protein expression by densitometry. (F-H) Immunofluorescence of p-IRE1α, p-PERK and ATF6 in each group’s lung alveolar/airway epithelial cells (×200). Data represent the mean ± SD. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001