Fig. 1

sEH deficiency mitigated changes in weight, lung function, and alveolar disruption after CS exposure. (A) Genotype identification result. (B) Western blot displaying variation in the protein expression of sEH in the lung tissue of each group. (C) Quantification of sEH protein expression by densitometry. (D, E) Changes in mouse body weight of each group after 16 weeks of exposure to air or CS; body weight was measured once a week. (F-J) Pulmonary function changes in each group. (F) Rrs and (G) Rn were significantly elevated; (I) G and (J) H were decreased after CS exposure. sEH deficiency inhibited Rrs and Rn, and promoted G and H. (H) Crs did not differ between the Air and CS groups. (K) Pathological manifestation in lung tissue by HE staining (×200). (L, M) Comparison of MLI and MAN in four groups. Data represent the mean ± SD. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001