Fig. 4

Expressions of pro-inflammatory mediators are reduced by cAMP in IgG-IC-stimulated acute lung injury. Mice are treated by intraperitoneal injection of DMSO or Rolipram (1 mg/kg), which is followed by immediate airway deposition of IgG-IC. 4 h later, BAL fluids are harvested, and levels of TNF-α (A), MIP-1α (B), MIP-1β (C), KC (D), and MIP-2 (E) are measured, respectively. Data are expressed as mean ± SEM (N = 6 for control groups, and N = 10 for IgG-IC groups). *** suggests p < 0.001