Fig. 1From: The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic miceEffects of TFPI2 knockdown on cardiac remodeling and function recovery after MI(a, b) Western blot analysis and immunohistochemical staining of TFPI2 in the myocardium of mice at 3 weeks after MI (n = 3). (c, d) Western blot analysis and TFPI2 staining to verify TFPI2 knockdown. (e) Images of the infarct and border zones after Masson’s trichome staining of the myocardial samples at 3 weeks after infarction, and quantitative analysis of the fibrosis area (n = 3). (f) Quantitative analysis of function recovery using echocardiography (n = 4). Sham, sham operation (magnification: ×100); MI, myocardial infarction; DM, diabetes mellitus; sh-TFPI2, sh-TFPI2 transfection; sh-NC, sh-NC transfection. Data represent mean ± standard deviation (SD). Data were analyzed using one-way ANOVA and Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001Back to article page