Fig. 4

Alternative splicing coordinates with RBP genes in sepsis patients and healthy donors. A Enriched GO biological processes showing the top 15 genes showing variable splicing events that were associated with differentially expressed RBP genes. B A boxplot is shown that indicates the co-disturbed RBP expression profiles in sepsis patients and healthy controls. C The co-disturbed network is shown that was constructed between the DE RBP expression values and the splicing ratio for the RAS events (pSAR >= 50%) using 79 samples (sepsis patients and healthy controls). Samples were retained that exhibited a Pearson’s correlation >= 0.7 and a P-value <= 0.01. Co-disturbed RAS and RASG that were involved in the most highly enriched GO terms (furthest right) are indicated in blue. The validation of NOP14 and ILF3 in sepsis patients (D-E)