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Fig. 4 | Journal of Inflammation

Fig. 4

From: Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis

Fig. 4

NaPyr regulates CSE-induced ferroptosis in A549 and BEAS-2B cells through the GPX4/Nrf2 pathway. (A) Protein expression levels of Nrf2 and GPX4 of A549 protein expression was measured by western blotting. (n = 3;##P < 0.01 vs. Control; **p < 0.01 vs. CSE) (B) Protein expression levels of Nrf2 and GPX4 of BEAS-2B protein expression was measured by western blotting. (n = 3;##P < 0.01 vs. Control; **p < 0.01 vs. CSE) (C) mRNA expression of GPX4 in A549 measured with qPCR. (n = 3;#P < 0.05 vs. Control; **p < 0.01 vs. CSE) (D) mRNA expression of Nrf2 in A549 measured with qPCR. (n = 3;#P < 0.05 vs. Control; **p < 0.01 vs. CSE) (E) mRNA expression of GPX4 in A549 measured with qPCR. (n = 3;##P < 0.01 vs. Control;*P < 0.05,**p < 0.01 vs. CSE) (F) mRNA expression of Nrf2 in BEAS-2B measured with qPCR. (n = 3;##P < 0.01 vs. Control; **p < 0.01 vs. CSE)

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Journal of Inflammation

ISSN: 1476-9255

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