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Fig. 3 | Journal of Inflammation

Fig. 3

From: Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis

Fig. 3

NaPyr inhibits CSE-induced ferroptosis in A549 cells. (A) Total Fe content of BEAS-2B cells in each group after CSE induction. (n = 4;##P < 0.01 vs. Control; **p < 0.01 vs. CSE) (B) The fluorescence intensity of MitoSOX in BEAS-2B was observed by fluorescence microscope. Scale bar = 100 μm (n = 3;##P < 0.01 vs. Control;**p < 0.01 vs. CSE) (C) GSH content in BEAS-2B after CSE stimulation and the intervention of NaPyr pretreatment. (n = 4;##P < 0.01 vs. Control;*P < 0.05,**p < 0.01 vs. CSE) (D) Napyr pretreatment can reduce the generation of ROS induced by CSE. Scale bar = 100 μm (n = 3;##P < 0.01 vs. Control;**p < 0.01 vs. CSE) (E) MDA levels in BEAS-2B of different experimental groups. (n = 4;##P < 0.01 vs. Control;**p < 0.01 vs. CSE) (F) The effect of CSE on MMP in BEAS-2B and the pretreatment effect of Napyr. Scale bar = 100 μm (n = 3;##P < 0.01 vs. Control;**p < 0.01 vs. CSE)

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Journal of Inflammation

ISSN: 1476-9255

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