Table 1 Potential Approaches for Targeting NETs for ACS

PAD4

CL-amidine

PAD4 Inhibitor

Blocking histone guanylation in NETosis

[70,71,72]

DNA matrixes

DNase I

DNA degradation

Degradation of the DNA composition of NETs

[73, 74]

NADPH/ROS

N-acetylcysteine, 5-Aminosalicylic acid, Kaem

Antioxidant

Inhibition of NADPH oxidase-ROS-dependent pathway

[77]

Citrulline protein

Anti citrulline protein antibody

Antibodies NET-inhibiting

Inhibitting the formation and uptake of NETs by macrophages

[92]

Platelet

Heparin

Aspirin

Anticoagulant

Selectiveing inhibition of platelet aggregation and NETs formation

[81, 82]

Inflammatory mediators

TLR

antagonists,CXCR blockers, Homocysteine (HHcy), Colchicine

Inflammatory mediator receptor blockers

Acting by inhibiting inflammatory vesicle activity to reduce the load of NETs in recent myocardial infarction or stroke

[86,87,88,89,90,91]