Fig. 3

Immune infiltration landscape in DRG tissue and screened Hub genes related to immune traits by WGCNA. A Box chart, the difference of immune cell infiltration between the control group and the SNI group (symbol "*", "**", and "ns" respectively represent p-value < 0.05, p-value < 0.01, and non-significance.); (B) Heat map of the correlation of 28 types immune cells, the pie chart will be displayed only when the correlation P < 0.05, color represents correlation, color depth represents correlation significance. The darker the red represents the more significant the positive correlation, the darker the blue represents the more significant the negative correlation; (C) Network topology analysis under various soft threshold power. When the power value was 4, the independence degree was ≥ 0.85. (On the left: The X-axis shows the soft threshold power. The Y-axis reflects the fit index of the scaled-free topological model. On the right: The X-axis shows the soft threshold power. The Y-axis represents average connectivity (degree)); (D) The clustering tree and co-expression network of co-representation network modules are constructed based on 1-TOM matrix; (E) Correlation of modules (column) with immune traits (row). Red represents positive correlation, blue, negative correlation. Each unit includes correlation coefficient and p value. F Scatter plot showed the correlation between gene significance (GS > 0.5) and module membership (MM > 0.8). G Venn diagram, the intersection genes between module genes and DEGs