Fig. 2

The differentially expressed genes (DEGs) in Dorsal root ganglion (DRG) tissues and enriched analysis. A UMAP diagram, the sample distribution of each dataset before the batch effect is removed, and each point represents a sample; (B) the sample distribution of each dataset after removing the batch effect; (C) Heat map of DEGs, the color represents expression level, the higher expression level, the darker the color (red for up-regulation and blue for down-regulation). The tree cluster on the left represents significant clustering results in different samples; (D) Volcano map of DEGs, red represents significantly up-regulated genes, blue represents significantly down-regulated genes, and gray represents genes with no significant differences. E Gene Ontology (GO) enrichment analysis bubble diagram, the ordinate is the name of GO and the abscissa is the proportion of genes. The circle size represents the count of DEGs enriched in the GO (the larger the circle, the more DEGs are enriched), and the color represents enrichment significance (the redder the color is, the more significant the DEGs are enriched on this GO). GO analysis includes biological processes (BP), cellular components (CC) and molecular functions (MF); (F) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis bubble diagram: the circle size represents the count of DEGs enriched to the pathway, the color represents significance