Fig. 6

Workflow employed to construct a comprehensive molecular interaction map to examine acute inflammation. The process began with the identification of seed molecules (left panel). This was followed by literature mining and the extraction of experimentally validated interacting molecular partners using several databases (middle). The final step (right) was to integrate experimentally validated regulatory layers of transcription factors, miRNA, and long non-coding RNAs from state-of-the-art databases. Various metabolites associated with acute inflammation and inflammation resolution were included together with their biosynthesis and signaling pathways. These maps are publicly available at https://air.bio.informatik.uni-rostock.de