Fig. 4

Respiratory mechanics. (A) Snapshot perturbation; resistance (R), elastance (E), and compliance (C). As the lung is seen as a single compartment, the parameters (R, E, and C) are indicative of the whole thorax (chest wall and lung). (B) Primewave-7 perturbation; airway resistance (Rn), tissue damping or resistance (G), and tissue elasticity (H). As the lung is seen as multiple compartments, Rn, G, and H can differentiate airways. (C) Airway responsiveness to increasing doses of methacholine measured by airway resistance. ^*vs. control, ^#vs. asthma; ^*p < 0.05, ^**p < 0.01, ^***p < 0.001; n.s., not significant