The immunological function of CXCR2 in the liver during sepsis

Journal of Inflammation

Table 2 CXC chemokines and their receptors in the liver

Systematic name (mouse, human)	Name (mouse)	Name (human)	Chemotaxis	Receptors (mouse, human)	Expressed cells	CXCR2 Affinity (EC50, nmol/L)
CXCL1	KC	GRO-α, GRO1, MGSA-α, NAP-3	Neu, LSEC, Bas	CXCR1, CXCR2	Neu, Mon, Eos, Epi, LSECs, T cells	5
CXCL2	MIP-2	GRO-β, GRO2, MGSA-β, MIP-α	Neu, LSEC, Bas	CXCR2	Neu, T cells, Mac	4
CXCL3	DCIP-1	GRO-γ, GRO3, MGSSA-γ, MIP-β	Neu, LSEC, Bas	CXCR2	T cells, LSECs, Mac	1
CXCL5	LIX	ENA-78	Neu, LSEC	CXCR2	Eos, Epi, LSECs, Mac	11
CXCL6	N/A	GCP-2	Neu, LSEC	CXCR1, CXCR2	LSECs, Mac, Neu	N/A
CXCL7	NAP-2	PPBP, NAP-2	Neu, LSEC, Bas	CXCR1, CXCR2	Mon, T cells, DCs, Mac	7
CXCL8	N/A	IL-8, NAP-1	Neu, LSEC, Bas, Mon	CXCR1, CXCR2	Mon, T cells, Mac, Epi, Hepa, LSECs, Neu	4

GRO-α/β/γ Growth-related oncogene, IL-8 Interleukin-8, ENA-78 Epithelial cell-derived neutrophil-activating protein-78, PPBP Pro-platelet basic protein, NAP-2 Neutrophil-activating peptide-2, GCP Granulocyte chemotactic protein 2, KC Keratinocyte-derived chemokine, MIP-2 Macrophage inflammatory protein-2, LIX Lipopolysaccharide-induced CXC human chemokine, DCIP-1 Dendritic cell inflammatory protein-1, Neu Neutrophils, LSECs Liver sinusoidal endothelial cells, Bas Basophils, Eos Eosinophils, Mon Monocytes, Mac Macrophages, Hepa Hepatocytes, HSCs Hepatic stellate cells, Epi Epithelial cells, DCs Dendritic cells, EC50 half maximal effective concentration

ISSN: 1476-9255