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Fig. 8 | Journal of Inflammation

Fig. 8

From: 5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cellsĀ and M1 polarization in macrophages

Fig. 8

A proposed model illustrated the mechanism by which 5-methoxyflavone protected against LPS-induced lung injury. 5-Methoxyflavone has the capacity to activate Nrf2/HO-1 signaling, which resulted in attenuating the pro-inflammatory through suppression of TLR4/NOX4/ROS/NF-ĪŗB/P38 MAPK signaling in BEAS-2B cells. Furthermore, the activation of Nrf2/HO-1 signaling by 5-methoxyflavone inhibited activation of STAT1 signaling, and subsequently suppressed M1 macrophage polarization and repolarization of M2 macrophages into M1

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Journal of Inflammation

ISSN: 1476-9255

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