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Fig. 6 | Journal of Inflammation

Fig. 6

From: Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Fig. 6

Proteomics results and functional network analysis of THP-1 macrophages with silenced PAD2 that were activated to the M1 phenotype. Silencing PAD2 upregulated pathways related to the antiviral innate immune response and interferon signalling. Volcano plot of differentially expressed proteins showing the log2 ratio of protein expression versus -log10 p value. A PAD2-silenced macrophages (siPAD2) compared to scrambled siRNA control (siCON) and B PAD2-silenced macrophages treated with LPS (siPAD2 + LPS) compared to scrambled siRNA control treated with LPS (siCON + LPS). The most upregulated and downregulated proteins are shown. C Enriched functional network in PAD2-silenced macrophages (siPAD2) compared to scrambled siRNA control (siCON), as generated by PINE. D Enriched functional network in PAD2 silenced macrophages (siPAD2 + LPS) treated with LPS compared to scrambled siRNA control treated with LPS (siCON + LPS), as generated by PINE. Activated pathways are shown as orange central nodes and inhibited pathways are shown as blue central nodes along with red (upregulated) or blue (downregulated) protein nodes. q value< 0.05; n = 6

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Journal of Inflammation

ISSN: 1476-9255

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