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Fig. 3 | Journal of Inflammation

Fig. 3

From: Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Fig. 3

Proteomics results of THP-1 macrophages activated to the M1 and M2 phenotypes in the presence of the pan-PAD inhibitor BB-Cl-amidine. The acquired data allowed for the identification and quantitation of 3005 protein groups across all biological conditions. Volcano plot of differentially expressed proteins showing the log2 ratio of protein expression versus -log10 p value. A LPS-treated macrophages compared to control, B IL-4-treated macrophages compared to control, C BB-Cl-treated macrophages compared to control, and D LPS-treated macrophages stimulated with BB-Cl compared to LPS, D) IL-4-treated macrophages stimulated with BB-Cl compared to IL-4. The most upregulated and downregulated proteins are shown. q value< 0.05; n = 5

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Journal of Inflammation

ISSN: 1476-9255

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