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Fig. 1 | Journal of Inflammation

Fig. 1

From: Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Fig. 1

Protein arginine deiminase (PAD) expression in macrophages polarized to proinflammatory (M1) and anti-inflammatory (M2) phenotypes. PAD1, PAD2 and PAD4 expression was upregulated in M1 macrophages, while PAD2 was strongly downregulated in M2 macrophages. mRNA expression of PAD1, PAD2 and PAD4 in THP-1 macrophages treated with LPS (M1 phenotype) or IL-4 (M2 phenotype) for 48 h. mRNA expression of PAD3 was not present in THP-1 macrophages. Mean ± SEM; *p < 0.05, ***p < 0.001, ****p < 0.0001 compared to control; n = 5

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Journal of Inflammation

ISSN: 1476-9255

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