Fig. 5From: Influenza a virus triggers acute exacerbation of chronic obstructive pulmonary disease by increasing proinflammatory cytokines secretion via NLRP3 inflammasome activationHistopathological changes of rats treated with IAV. After 12Â weeks of cigarette-smoke exposure, the airspace was enlarged markedly, the number of alveoli was decreased and the desquamation of bronchiolar epithelial cells was obviously in the lung samples of the rats of the COPD groupBack to article page