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Table 2 Histology scores on micrographs of paw sections from control and adjuvant-induced arthritic Sprague-Dawley rats

From: Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund’s adjuvant-induced arthritis in Sprague-Dawley rats

 

Histology score

Prophylactic

Therapeutic

IFA

0

0

CFA

3

3

Dexamethasone (0.3 mg/kg)

1

1

HFE (50 mg/kg)

2

2

HFE (200 mg/kg)

2

2

HFE (500 mg/kg)

1

1

  1. Sprague-Dawley rats were injected sub plantar with 0.1 ml of IFA or CFA into the right hind
  2. paw. The drug vehicle, dexamethasone (0.3 mg/kg) and HFE (50, 200, 500 mg/kg) were administered orally 1 h before arthritis induction and thereafter until the 28th day in the prophylactic approach and started on the 14th day after the induction of arthritis and daily till the 28th day in the therapeutic approach. Bone tissue of the right hind limbs were sectioned, stained with haematoxylin-eosin and micrographs of the tissue were scored on a scale of 0–3: (0) absence of inflammation indicators [1]; mild inflammation [2]; moderate inflammation [3]; inflammation. Values shown are mean of n ≥ 5
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Journal of Inflammation

ISSN: 1476-9255

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