Fig. 1

Knocking out TRIP6 enhances murine resistance to DSS-induced colitis. a Weight loss was monitored in TRIP6^+/+ and TRIP6^−/− mice relative to baseline following treatment with 2.5% DSS and during a subsequent 6-day recovery period in which mice were allowed to drink regular water (n = 12/group). Data are means ± SD. *p < 0.05; **p < 0.01; ***p < 0.001, ns, not significant. b Representative images of colon tissues are shown (top) and colon length is represented as a ratio (cm:g) relative to the starting weight of mice prior to DSS administration (bottom). Data are means ± SD. ns, not significant; ***p < 0.001. c H&E staining was used to assess TRIP6^+/+ and TRIP6^−/− murine colon tissue sections on days 7 and 13 following DSS treatment, with representative images being shown. d Inflammation, depth of inflammation, and crypt damage were scored for samples of colon tissue from TRIP6^+/+ and TRIP6^−/− mice following treatment with DSS