Table 1 Presentation of SNPs TGFβ genes on the base of the NCBI gene database, available on https://www.ncbi.nlm.nih.gov
From: TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
Name/Gene ID | Description | Location | Aliases | MIM | SNPs | Role in asthma |
|---|---|---|---|---|---|---|
TGFB1 ID: 7040 | transforming growth factor beta 1 [Homo sapiens (human)] | Chromosome 19, NC_000019.10 (41,330,323..41353922, complement) | CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta | 190,180 | rs8109627, rs8179181, rs4803455, rs1800469, rs11083616 | dimerization and phosphorylation of receptor-activated Smad proteins |
TGFB2 ID: 7042 | transforming growth factor beta 2 [Homo sapiens (human)] | Chromosome 1, NC_000001.11 (218,345,284..218444619) | G-TSF, LDS4, TGF-beta2 | 190,220 | rs10495098, rs17047703, rs17558745, rs2799085, rs2009112, rs10482751, rs2027567, rs10779329, rs2796821, rs2796822, rs4846479, rs2798631, rs10863399 | expressed by eosinophils; predominant in severe allergic asthma |
TGFB3 ID: 7043 | transforming growth factor beta 3 [Homo sapiens (human)] | Chromosome 14, NC_000014.9 (75,958,061..75983011, complement) | ARVD, ARVD1, LDS5, RNHF, TGF-beta3 | 190,230 | rs4903359, rs3917187, rs2284792, rs2268626 | lung cells become TGF-β3 positive under inflammatory conditions |