Fig. 4

Bullatacin promotes the release of HMGB1, HSP90 and HSP70 in late apoptotic cells. A ELISA was used to analyse the concentration of HMGB1 in the supernatant of SW480 and HT-29 cells treated with bullatacin for the indicated times. Significance:**P < 0.01 versus control. B ELISA was used to analyse the concentration of HSP90 in the supernatant of SW480 and HT-29 cells treated with bullatacin for the indicated times. Significance: **P < 0.01 versus control. C ELISA was used to analyse the concentration of HSP70 in the supernatant of SW480 and HT-29 cells treated with bullatacin for the indicated times. Significance: **P < 0.01 versus control