Fig. 6
The experimental set-up. a A custom-made LIUS generating device (Korust, Korea). The ultrasound generating device allows for adjusting the intensity range from 20 to 1000 mW/cm2 and the treatment time through the control box (left panel). The device has two probes with 11 mm in diameter customized for animal experiments (middle panel). A probe was placed on top of the hind paw of a rat for LIUS stimulation (right panel). b A schematic diagram showing the study protocol in vivo. The rats were stimulated with LIUS (50–200 mW/cm2) for 10 min right after carrageenan injection, and then the paw tissue was analyzed at a given time points from 1 h to 72 h depending on assays