Fig. 5
From: Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression
circRNA-CDR1as/miR-641/FGF-2 promotes the extracellular matrix metabolism and inflammatory process of OA chondrocytes by activating the MEK/ERK signaling pathway. a FGF-2 expression is upregulated in OA chondrocytes. b Upregulated FGF-2 in OA chondrocytes was abolished by circRNA-CDR1as siRNA. c Luciferase activity assay showed that the expression of FGF-2 was mediated by abolished in cells transfected with vectors containing 3′ UTR-wt of FGF-2 as well as miR-641 mimic. d Transfection of si-FGF-2 inhibited expression of MMP13, IL-6 and RUNX2, but enhanced expression of Col II. e Transfection of circRNA-CDR1as siRNA or cotransfected with miR-641 decreased the levels of FGF-2, p-MEK1/2 and p-ERK1/2