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Table 1 The genes implicated in mucosal barrier function that confer risk to UC [27,28,29]

From: Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies

GENE LOCUS SNP PROTEIN NAME FUNCITON
ECM1 1q21 rs3737240 Extracellular matrix protein 1 Glycoprotein involved in cell proliferation
CDH1 16q22 rs12597188 E-cadherin Protein involved in epithelial adherens junction
HNF4A 20q13 rs6017342 Hepatocyte nuclear factor 4α Transcriptional factor that regulates cellular differentiation along crypt-villus axis
LAMB1 7q31 rs886774 Laminin β1 Protein involved in cell adhesion and differentiation
IL10 1q32 rs3024505 Interleukin 10 Anti-inflammatory cytokine