From: Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies
GENE | LOCUS | SNP | PROTEIN NAME | FUNCITON |
---|---|---|---|---|
ECM1 | 1q21 | rs3737240 | Extracellular matrix protein 1 | Glycoprotein involved in cell proliferation |
CDH1 | 16q22 | rs12597188 | E-cadherin | Protein involved in epithelial adherens junction |
HNF4A | 20q13 | rs6017342 | Hepatocyte nuclear factor 4α | Transcriptional factor that regulates cellular differentiation along crypt-villus axis |
LAMB1 | 7q31 | rs886774 | Laminin β1 | Protein involved in cell adhesion and differentiation |
IL10 | 1q32 | rs3024505 | Interleukin 10 | Anti-inflammatory cytokine |