Fig. 4

Alleviated effects of skin inflammation in ear edema models (a, b: measurement of ear weight, c: myeloperoxidase assay, d: eosinophil assay). KRO-105714 solution was applied to the ears of ICR mice twice in 15 min and 6 h after application of TPA (a, c) or in 0 h and 6 h after application of oxazolone (b, d). a, b After 24 h, a whole ear weight was measured using an electronic balance. Then, expression levels of MPO (c) or EPO (d) in ear skin were analyzed. Data are shown as mean ± standard deviation (SD). NS: not significant; NS: not significant; *P < 0.05, ** P < 0.01 and *** P < 0.001 versus compound-untreated cells (ANOVA multiple comparison)