Fig. 7From: Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytesA schematic of the proposed mechanism. During degeneration, MAPK and NF-κB signaling are activated by IL-1β stimulation. UA treatment can decrease iNOS, COX2, and MMPs expression and increase matrix gene expression through inhibiting activation of the MAPK and NF-κB pathwaysBack to article page