Fig. 1

Serp-2 treatment improves survival following liver ischemia-reperfusion injury. (a) Experimental outline. Mice were treated with Serp-2, M-T7 or saline (treatment; TX) 30 min prior to induction of 70% ischemia-reperfusion maintained for 90 min and were treated with Serp-2, M-T7 or saline on alternating days for 10 days. (b) ALT levels in the serum of sham-operated mice or mice treated with saline, Serp-2 or M-T7 mice with ischemia-reperfusion injury at 24 h post-procedure. Statistics calculated by one-way ANOVA with Fisher’s PLSD post-hoc analysis (N = 2–6 mice per group). (c) Mice treated with Serp-2 (magenta triangles) had significantly improved survival outcomes compared with mice treated with saline, while mice treated with M-T7 (teal squares) did not show improved survival. Kaplan Meier curve statistics calculated by Log-rank (Mantel-Cox) test (N = 7–8 mice per group)