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Fig. 4 | Journal of Inflammation

Fig. 4

From: Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

Fig. 4

Association of free cholesterol and oxLDL with chicken-wire fibrosis in NAFLD. The surgical specimens were stained with an antibody against oxLDL (a), antibodies against oxLDL and αSMA (b), trichrome (c), filipin (d), an antibody against CD31 (e), and an antibody against LOX-1 (f). Chicken-wire fibrosis was observed through trichrome staining. oxLDL and free cholesterol were observed in the fibrotic parenchyma of cirrhosis (arrow) and were also associated with each other. Activated stellate cells (marked by αSMA without CD31 in the surrounding environment) infiltrated the fibrotic parenchyma, where oxLDL and free cholesterol were accumulated. The phenomenon was prominent adjacent to the portal vein (arrowheads). LOX-1 expression in the fibrotic parenchyma was not high and was not closely related to oxLDL accumulation. a high-power field of magnification is shown in Additional file 4: Figure S3. Scale bar: 100 μm

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Journal of Inflammation

ISSN: 1476-9255

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