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Table 1 Changes of macro- and microcirculatory parameters at baseline, 6 h, 30 h and 54 h. Values are presented as mean ± SD

From: LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

Group

Sham

CLP

CLP + LDK378

MAP (mmHg)

 BL

124 ± 5.70

124.8 ± 6.91

123.2 ± 4.38

 6 h

120 ± 6.78

99.6 ± 9.24*

98 ± 4.74*

 30 h

113.4 ± 11.72

69.6 ± 12.93*

86.4 ± 5.68*#

 54 h

115.2 ± 6.38

46 ± 13.08*

74.4 ± 7.06*#

PVD (mm/mm2)

 BL

18.91 ± 0.756

18.24 ± 0.62

18.63 ± 0.51

 6 h

18.9 ± 0.56

16.44 ± 2.61*

16.87 ± 1.14

 30 h

18.45 ± 0.45

13.56 ± 2.19*

16.14 ± 1.33*#

 54 h

18.63 ± 0.86

12.45 ± 2.41*

15.49 ± 1.01*#

MFI

 BL

2.9 ± 0.14

2.9 ± 0.14

2.95 ± 0.11

 6 h

2.85 ± 0.14

2.55 ± 0.27

2.6 ± 0.45

 30 h

2.7 ± 0.11

1.85 ± 0.22*

2.3 ± 0.33*#

 54 h

2.55 ± 0.21

1.5 ± 0.18*

2.05 ± 0.33*#

  1. BL indicates baseline, MAP mean arterial pressure, MFI microcirculatory flow index, PVD perfused vessel density. *p < 0.05 compared with Sham group; #p < 0.05 compared with CLP group