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Table 1 Changes of macro- and microcirculatory parameters at baseline, 6 h, 30 h and 54 h. Values are presented as mean ± SD

From: LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

Group Sham CLP CLP + LDK378
MAP (mmHg)
 BL 124 ± 5.70 124.8 ± 6.91 123.2 ± 4.38
 6 h 120 ± 6.78 99.6 ± 9.24* 98 ± 4.74*
 30 h 113.4 ± 11.72 69.6 ± 12.93* 86.4 ± 5.68*#
 54 h 115.2 ± 6.38 46 ± 13.08* 74.4 ± 7.06*#
PVD (mm/mm2)
 BL 18.91 ± 0.756 18.24 ± 0.62 18.63 ± 0.51
 6 h 18.9 ± 0.56 16.44 ± 2.61* 16.87 ± 1.14
 30 h 18.45 ± 0.45 13.56 ± 2.19* 16.14 ± 1.33*#
 54 h 18.63 ± 0.86 12.45 ± 2.41* 15.49 ± 1.01*#
MFI
 BL 2.9 ± 0.14 2.9 ± 0.14 2.95 ± 0.11
 6 h 2.85 ± 0.14 2.55 ± 0.27 2.6 ± 0.45
 30 h 2.7 ± 0.11 1.85 ± 0.22* 2.3 ± 0.33*#
 54 h 2.55 ± 0.21 1.5 ± 0.18* 2.05 ± 0.33*#
  1. BL indicates baseline, MAP mean arterial pressure, MFI microcirculatory flow index, PVD perfused vessel density. *p < 0.05 compared with Sham group; #p < 0.05 compared with CLP group