Fig. 6
The inflammasome mediates oxidative stress resulting in LDH release and production of ROS: Bar graph of LDH released by human fibroblasts (49 y/o) after exposure to hydrogen peroxide (25 μM H2O2) for 30 min (a) and in 52 y/o cells after inhibition of caspase-1 with YVAD (b). Cellular ROS production after challenge of 52 y/o fibroblasts with 25 μM H2O2 for 30 min and inhibition of caspase-1 with YVAD (c)