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Table 2 Maximum recorded cytokine values as well as fold change from baseline (2 weeks pre-injury) of systemic cytokines throughout the post-injury period (t = 0 to post-injury day 14) from the trauma and hemorrhage model (THM) and polytrauma and hemorrhage model (PHM)

From: The impact of septic stimuli on the systemic inflammatory response and physiologic insult in a preclinical non-human primate model of polytraumatic injury

  Maximum Recorded Serum Level
Polytrauma and Hemorrhage Model Trauma and Hemorrhage Model  
Maximum (pg/mL) Fold change Maximum (pg/mL) Fold change P-value
IL-6 7887 ± 2521 6149 1076 ± 483 1159 0.015
IL-1ra 34,498 ± 5987 2286 2511 ± 1229 725 0.000
IL-10 13,411 ± 5598 785 617 ± 252 50 0.034
G-CSF 1652 ± 1912 51 201 ± 192 15 0.003
MCP-1 8419 ± 2297 19 4064 ± 1140 4.5 0.104
IL-1β 27 ± 71 19 0.5 ± 0.2 1.0 0.103
IFNγ 40 ± 126 18 4.7 ± 6.8 2.6 0.208
TNF 289 ± 558 11 2.6 ± 2.0 1.9 0.040
GM-CSF 30 ± 41 7.4 1.4 ± 1.5 5.1 0.006
IL-15 19 ± 18 3.8 13 ± 4.4 10.5 0.092
MIP-1α 47 ± 52 3.5 12 ± 16 1.4 0.016
IL-8 2056 ± 2190 3.0 1280 ± 737 1.3 0.140
IL-2 19 ± 22 2.1 10.4 ± 5.5 1.5 0.112
TGFα 50 ± 87 2.1 37 ± 15 2.0 0.534