Table 2 Maximum recorded cytokine values as well as fold change from baseline (2 weeks pre-injury) of systemic cytokines throughout the post-injury period (t = 0 to post-injury day 14) from the trauma and hemorrhage model (THM) and polytrauma and hemorrhage model (PHM)
| Â | Maximum Recorded Serum Level | ||||
|---|---|---|---|---|---|
Polytrauma and Hemorrhage Model | Trauma and Hemorrhage Model | Â | |||
Maximum (pg/mL) | Fold change | Maximum (pg/mL) | Fold change | P-value | |
IL-6 | 7887 ± 2521 | 6149 | 1076 ± 483 | 1159 | 0.015 |
IL-1ra | 34,498 ± 5987 | 2286 | 2511 ± 1229 | 725 | 0.000 |
IL-10 | 13,411 ± 5598 | 785 | 617 ± 252 | 50 | 0.034 |
G-CSF | 1652 ± 1912 | 51 | 201 ± 192 | 15 | 0.003 |
MCP-1 | 8419 ± 2297 | 19 | 4064 ± 1140 | 4.5 | 0.104 |
IL-1β | 27 ± 71 | 19 | 0.5 ± 0.2 | 1.0 | 0.103 |
IFNγ | 40 ± 126 | 18 | 4.7 ± 6.8 | 2.6 | 0.208 |
TNF | 289 ± 558 | 11 | 2.6 ± 2.0 | 1.9 | 0.040 |
GM-CSF | 30 ± 41 | 7.4 | 1.4 ± 1.5 | 5.1 | 0.006 |
IL-15 | 19 ± 18 | 3.8 | 13 ± 4.4 | 10.5 | 0.092 |
MIP-1α | 47 ± 52 | 3.5 | 12 ± 16 | 1.4 | 0.016 |
IL-8 | 2056 ± 2190 | 3.0 | 1280 ± 737 | 1.3 | 0.140 |
IL-2 | 19 ± 22 | 2.1 | 10.4 ± 5.5 | 1.5 | 0.112 |
TGFα | 50 ± 87 | 2.1 | 37 ± 15 | 2.0 | 0.534 |