Fig. 6From: Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapyEffect of tofacitinib on intrarectally infused IFNγ-induced pSTAT1 production in mouse colon. Data (mean ± SEM, n = 4–11) are expressed with respect to (a) dose and (b) concentration. (c) Concentration/response curve to tofacitinib in the mouse isolated colon with respect to IFNγ-induced pSTAT1 production (mean ± SEM, n = 3–18)Back to article page